Results 41 to 50 of about 74,013 (289)

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender, Lauren Pommert, Lori R. Backus, Andrea Bidwell, Courtney Blank, Erin H. Breese, Karen C. Burns, Adam Lane, Lynn H. Lee, Benjamin Mizukawa, Robin E. Norris, Maureen M. O'Brien, Daniel Peck, Christine Phillips, Thomas D. Ryan, Jennifer Young, Michael Absalon, John P. Perentesis   +17 more
wiley   +1 more source

Law-Based Arguments and Messages to Advocate for Later School Start Time Policies in the United States [PDF]

, 2017
The increasing scientific evidence that early school start times are harmful to the health and safety of teenagers has generated much recent debate about changing school start times policies for adolescent students.
Lee, Clark J, Lockley, Steven W, Nolan, Dennis M, Pattison, Brent   +3 more
core   +2 more sources

Improving the Evaluation and Management of Transfusion‐Related Iron Overload in Children, Adolescents, and Young Adults Following Cancer Treatment or Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Transfusion‐related iron overload (TRIO) is a late effect of therapy impacting survivors of childhood cancer and hematopoietic stem cell transplantation (HSCT) who receive frequent packed red blood cell (pRBC) transfusions. Surprisingly, there are no accepted guidelines to assist providers in identifying and treating at‐risk ...
Luke Gingell, Allison Close, Guoli Zhou, Troy C. Quigg   +3 more
wiley   +1 more source

Determinants of Meningococcal ACWY vaccination in adolescents in the US: completion and compliance with the CDC recommendations

Human Vaccines & Immunotherapeutics, 2020
Since 2011, the Advisory Committee on Immunization Practices (ACIP) guidelines for routine MenACWY vaccination in the US include a primary dose before age 16 y, preferably at ages 11-12 y, with a booster dose at age 16 y.
Wendy Y. Cheng, Rose Chang, Patricia Novy, Cristi O’Connor, Mei Sheng Duh, Cosmina S. Hogea   +5 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Attitudes Toward Seat Belt Use Among Urban & Rural Teens [PDF]

, 2007
Motor vehicle crashes are a leading cause of death among 15 to 20 year-olds in the United States. In Missouri, young drivers are involved in a disproportionate number of fatal traffic crashes.
Diener, Jeremy, Richardson, Lilliard E. Jr.   +1 more
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

An Exploratory Study: Performance Differences Between Novice Teen and Senior Drivers Using Interactive Exercises on a Driving Simulator

Safety
Clinicians who do not specialize in driving have a need for simple assessment tools for both the aging population and new drivers. While many researchers focus on complex driving scenarios presented on simulators or on-road driving, this exploratory ...
Johnell O. Brooks, Rakesh Gangadharaiah, Patrick J. Rosopa, Casey Jenkins, Elenah B. Rosopa, Rebecca Pool, Lauren Mims, Breno Schwambach, Timothy Jenkins, Ken Melnrick   +9 more
doaj   +1 more source

Thematic Analysis of Videos Suggests That YA Space Design Should Be User-Driven, User-Centered, and Flexible Enough to Enable Multiple Uses

Evidence Based Library and Information Practice, 2015
A Review of: Agosto, D. E., Bell, J. P., Bernier, A. & Kuhlmann, M. (2015). “This is our library, and it’s a pretty cool place”: A user-centered study of public library YA spaces. Public Library Quarterly, 34(1), 23-43.
Ann Glusker
doaj   +1 more source

Accid Anal Prev [PDF]

ObjectiveTeens\u2019 crash risk is highest in the first years of independent driving. Circumstances surrounding fatal crashes have been widely documented, but less is known about factors related to nonfatal teen driver crashes.

core   +3 more sources