Results 81 to 90 of about 74,013 (289)

Using the Functional Object Detection—Advanced Driving Simulator Scenario to Examine Task Combinations and Age-Based Performance Differences: A Case Study

Applied Sciences
Occupational therapists need objective tools to evaluate and provide interventions that promote the recovery and rehabilitation of clients. Driving, a common goal for clients after an injury or illness, is a complex task that relies on visual, cognitive,
Johnell O. Brooks, Rakesh Gangadharaiah, Elenah B. Rosopa, Rebecca Pool, Casey Jenkins, Patrick J. Rosopa, Lauren Mims, Breno Schwambach, Ken Melnrick   +8 more
doaj   +1 more source

Spartan Daily, November 16, 2017 [PDF]

, 2017
Volume 149, Issue 37https://scholarworks.sjsu.edu/spartan_daily_2017/1078/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +1 more source

Facilitating Expedited Drug Approval– the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease

Arthritis Care &Research, Accepted Article.
Pamela F. Weiss, Hermine I. Brunner
wiley   +1 more source

Phenotypic Diversity and Outcomes in Pediatric NMDA Receptor Encephalitis: A 15‐Year Retrospective Study from the Largest Children's Hospital in the United States

Advanced Science, EarlyView.
ABSTRACT Anti‐NMDAR encephalitis (NMDARE) is an autoantibody‐mediated disorder characterized by seizures, movement disorders, neurocognitive deficits, and psychosis, but the complete phenotypic heterogeneity, and outcomes are incompletely understood in children.
Alexander J. Sandweiss, Timothy Erickson, Yike Jiang, Varun Kannan, Jonathan M. Yarimi, Kristen S. Fisher, Nikita Shukla, Tim Lotze, Eyal Muscal, Kristy O. Murray   +9 more
wiley   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Behavioral paтterns in the genesis of psychological disadaptation in representatives of youth subcultures in adolescent age

Психіатрія, неврологія та медична психологія, 2019
To determine the patronization of psychological maladjustment of the individual in the context of various models of socialization in the subcultural space, 143 adolescents were surveyed, among whom 93 respondents were representatives of youth subcultures:
Anastasia Chelakhova
doaj   +1 more source

Recommendations for a New Temporary Assistance for Needy Families (TANF) Program In Illinois [PDF]

, 2002
The Chicago Jobs Council has prepared this "tool" to guide our Governor-Elect, transition team members, legislators, and a new Department of Human Services administration in the transformation of the TANF program in Illinois.
Rose Karasti
core  

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Prepaid card models: a study in diversity [PDF]

Summary: On January 13, 2005, the Payment Cards Center of the Federal Reserve Bank of Philadelphia sponsored a workshop led by Gary Palmer, chief operating officer and co-founder of WildCard Systems, to examine the developing market for prepaid card ...
Julia S. Cheney
core