Advanced Science, EarlyView.Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu +13 more
wiley +1 more source
DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss
Advanced Science, EarlyView.Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim +11 more
wiley +1 more source
Forms of psycho-pedagogical work to overcome the negative factors in professional self-determination of teenagers with deviant behavior [PDF]
, 2017 Ekaterina A. Nikitskaya
openalex +1 more source
PERSONAL GROWTH DYNAMICS AND THE DEVELOPMENT LEVEL OF PERSONAL COPING RESOURCES OF TEENAGERS
, 2022 O.M. Serysheva
openalex +2 more sources
A percepção de terapeutas ocupacionais sobre suicídio e sua formação profissional para o manejo de adolescentes com comportamento suicida/The perception of occupational therapists on suicide and its their professional training for the management of suicidal behavior with teenagers [PDF]
, 2022 Yasmim da Siva Xavier +6 more
openalex +1 more source
Advanced Science, EarlyView.This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang +6 more
wiley +1 more source
Otoacustic Emission Test Abnormalities among Teenagers [PDF]
, 2012 André Luiz Lopes Sampaio +4 more
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XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss
Advanced Science, EarlyView.Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan +13 more
wiley +1 more source
Negative Impact of Divorce on Teenagers in District Chiniot, Pakistan
, 2023 Muhammad Shoaib Ali Bajwa Bajwa +2 more
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Advanced Science, EarlyView.We present Diffusion‐MRI‐based Estimation of Cortical Architecture via Machine Learning (DECAM), a deep‐learning framework for estimating primate brain cortical architecture optimized with best response constraint and cortical label vectors. Trained using macaque brain high‐resolution multi‐shell dMRI and histology data, DECAM generates high‐fidelity ...
Tianjia Zhu +7 more
wiley +1 more source