Results 121 to 130 of about 440,167 (290)
Income support and staying in school: what can we learn from Australia's AUSTUDY experiment? [PDF]
In Australia, as in most industrialised countries, there has been a dramatic increase in unemployment rates over the last three decades. The teenage labour market, in particular, has undergone significant structural changes which have resulted in large ...
Alexandra Heath, Lorraine Dearden
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Advanced Science, EarlyView.Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo +7 more
wiley +1 more source
Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion
Advanced Science, EarlyView.The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li +10 more
wiley +1 more source
When it comes to safeguarding children, there exists a confused story about what we think maturity is [PDF]
, 2012 In the wake of the Rochdale grooming case and questions surrounding child protection in schools, Tim Linehan discusses our misconceptions around maturity and what this means for child safeguarding.
Linehan, Tim
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First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria
Advanced Science, EarlyView.We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena +5 more
wiley +1 more source
HUBUNGAN ANTARA GROWTH MINDSET DENGAN GRIT PADA REMAJA GENERASI Z [PDF]
Gen Z is analogous as strawberry generation because they assumed to be creative, skilled, and critical, but are vulnerable to destruction or lack resilience when facing competition or obstacles.
Kharisma, Adelia Nur
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Advanced Science, EarlyView.Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan +11 more
wiley +1 more source
Performance in a Pitch Memory Task by Visually Handicapped Children and Youths
Archives of Acoustics, 2013 The present work discusses results concerning sound perception obtained in a pitch memorization experiment for blind and visually impaired subjects (children and teenagers). Listeners were divided into two age groups: 7–13 year olds and 14–18 year olds.
Edyta BOGUSZ +2 more
doaj
Family Life & Life Skills Education for Adolescents: Trivandrum Experience [PDF]
, 2005 Adolescence is a period of experimenting, experiencing and expanding. Adolescents need help and guidance in decision-making, problem solving, critical thinking, developing interpersonal skills, self-awareness, empathy, coping with stress and managing ...
M.K.C., Nair
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