Results 31 to 40 of about 6,355,244 (249)

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Multi-Objective Optimization of Gear Design of E-Axles to Improve Noise Emission and Load Distribution

Machines
This paper presents a comprehensive methodology to enable the optimization of an automotive electric axle to reduce noise emissions and improve load distribution.
Luciano Cianciotta, Marco Cirelli, Pier Paolo Valentini   +2 more
doaj   +1 more source

Protease‐Triggered Chromogenic Release From Peptide‐Modified Calcium Carbonate Microspheres Enables Colorimetric Detection of Porphyromonas gingivalis Activity

Advanced Science, EarlyView.
We report a chromogenic release‐based assay system with protease‐cleavage peptide‐modified calcium carbonate microspheres for colorimetric detection of Porphyromonas (P.) gingivalis activity. In response to Arg‐specific gingipain secreted by P. gingivalis, the supernatant becomes colored, enabling colorimetric analysis and providing the monitoring of ...
Yuki Hiruta, Zhicheng Jin, Mari Adachi, Lubna Amer, Natalia O. Tjokro, Diego F. Trujillo, Jan Potempa, Anthony J. O'Donoghue, Casey Chen, Jesse V. Jokerst   +9 more
wiley   +1 more source

Multi-Run Genetic Algorithm Approach for Optimal Design of Concentric Reluctance Magnetic Gears

Machines
This paper presents a systematic optimization methodology for reluctance magnetic gears (RMGs) using genetic algorithms to maximize peak torque within fixed volume constraints.
Silvia Roscioli, Valentin Mateev, Amedeo Amoresano, Luigi Pio Di Noia, Iliana Marinova   +4 more
doaj   +1 more source

Frequency and distribution of pulpal calcifications in teeth involved in jaw tumors [PDF]

, 2023
Pulp calcifications are idiopathic mineralized masses associated with irritation, age, trauma, and systemic or genetic diseases. The objective of this work was to examine frequency and distribution of pulp calcifications in teeth involved in jaw tumors ...
Santillán-Reyes, Ana Miriam, Toral-Rizo, Víctor Hugo, Hernandez-Soli, María Teresa, Hegazy-Hassa, Wael, Garduño-Mejía, José Edgar, Ibáñez-Mancera, Norma Guadalupe, Lara-Carrillo, Edith, Bologna-Molina, Ronell   +7 more
core   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Multiobjective optimization of water distribution systems accounting for economic cost, hydraulic reliability, and greenhouse gas emissions [PDF]

, 2013
Key Points Three‐objective WDS optimization considering cost, reliability and GHGs Shape of solution space formed by the objectives is a U‐shaped curve Location of Pareto front in the solution space and its practical implications Wenyan Wu, Holger R ...
Wu, W., Maier, H., Simpson, A.
core   +1 more source

Root‐Inspired Microneedle Patch With Interlocked Rigid‐Soft Architecture for High Tissue‐Adaptiveness

Advanced Science, EarlyView.
A root‐inspired microneedle array patch uses lattice‐based mechanical interlocking to unite rigid microneedles with a flexible substrate. The interlocked rigid–soft architecture improves interfacial bonding, supports stable adhesion on curved and wet tissues under dynamic motion, and provides a versatile platform for robust biointerfacing and future ...
Jongchan Lee, Yeongjun Song, Yonghyun Cho, Hyo In Kim, Dong‐Hyun Youn, Jinbong Park, Seungbeom Choi, Dohyun Kwon, Brian Jun Lee, Sangyul Baik   +9 more
wiley   +1 more source

Modeling Analysis and Simulation Verification for Drive Tooth Stress of Rubber Track Wheel

Jixie chuandong, 2019
The rubber track wheel generally transmits power by the engagement of the driving teeth of the rubber track and the driving pin of the driving wheel. The driving teeth are likely to be destroyed when they are subjected to excessive load or load impact ...
Zihan Zhao, Xihui Mu, Fengpo Du, Jianhua Guo   +3 more
doaj  

Tooth position prediction method based on adaptive geometry optimization.

PLoS ONE
A multi-layer feature optimization Transformer-based tooth position prediction method is proposed to address the problems of difficult access to high-precision medical data and the difficulty of capturing and representing hierarchical features and ...
Tian Ma, Yijie Zeng, Wenda Pei, Chao Li, Yuancheng Li   +4 more
doaj   +1 more source