Results 191 to 200 of about 4,245 (267)

Reducing risk for chronic disease: evaluation of a collective community approach to sustainable evidence-based health programming. [PDF]

open access: yesBMC Public Health
Oestman K   +14 more
europepmc   +1 more source

Evaluation of electrolyzed water to control fungal trunk pathogens in grapevine nurseries

open access: yesPest Management Science, Volume 81, Issue 4, Page 1740-1751, April 2025.
Electrolyzed water treatments could have promising applications in the grapevine nursery process to prevent or reduce infections caused by fungal trunk pathogens on grapevine propagation material. Abstract BACKGROUND Grapevine producers demand solutions to control fungal trunk pathogens (FTPs) in nurseries.
Mónica Berbegal   +6 more
wiley   +1 more source

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

open access: yesPhytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan   +8 more
wiley   +1 more source

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li   +6 more
wiley   +1 more source

Dietary Flavonoid Hyperoside Ameliorates High‐Fat Diet‐Induced Type 2 Diabetes Mellitus by Enhancing Brown Adipose Tissue Thermogenesis, White Adipose Tissue Browning, and Gut Microbiota Remodeling

open access: yesPhytotherapy Research, EarlyView.
Hyperoside ameliorates metabolic dysfunction in high‐fat diet‐induced type 2 diabetic mice, accompanied by enhanced brown adipose tissue thermogenic activity, inguinal white adipose tissue browning‐related changes, reduced M1 macrophage polarization, and gut microbiota remodeling.
WeiFeng Cai   +7 more
wiley   +1 more source

Investigation of the laser fluence and wavelength dependence in surface‐assisted laser desorption/ionization mass spectrometry using gold nanoparticles

open access: yesRapid Communications in Mass Spectrometry, EarlyView.
Rationale Surface‐assisted laser desorption/ionization (SALDI) mass spectrometry (MS) builds on the use of nanostructured surfaces (e.g., coatings of colloidal nanoparticles) to promote analyte desorption and ionization. The SALDI process is believed to occur mainly through thermal processes, resulting from heating of the nanosubstrate upon absorption ...
Wendy H. Müller   +3 more
wiley   +1 more source

Quantitative Imaging of Human Hemoglobin Binding to Staphylococcus aureus With Single‐Molecule Resolution

open access: yesSmall, EarlyView.
Single‐molecule localization microscopy is exploited to quantify the number of hemoglobin copies bound to specific receptors on S. aureus wall. This quantification supports the design of a photoactive derivative of hemoglobin able to photo‐inactivate S.
Pietro Delcanale   +10 more
wiley   +1 more source

Kirigami‐Inspired Deployable Microneedle Robot With Enhanced Conformability for Targeted Oral Drug Delivery

open access: yesSmall, EarlyView.
We have engineered a kirigami‐inspired deployable microneedle robot (KiriBot) capable of remotely controlled attachment to target tissues for sustained drug release. KiriBot incorporates a flexible structure that enhances conformability, improves adherence to irregular tissues, and facilitates microneedle insertion.
Kun Zhou   +11 more
wiley   +1 more source

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