Results 191 to 200 of about 4,171 (266)

Investigation of the laser fluence and wavelength dependence in surface‐assisted laser desorption/ionization mass spectrometry using gold nanoparticles

open access: yesRapid Communications in Mass Spectrometry, EarlyView.
Rationale Surface‐assisted laser desorption/ionization (SALDI) mass spectrometry (MS) builds on the use of nanostructured surfaces (e.g., coatings of colloidal nanoparticles) to promote analyte desorption and ionization. The SALDI process is believed to occur mainly through thermal processes, resulting from heating of the nanosubstrate upon absorption ...
Wendy H. Müller   +3 more
wiley   +1 more source

Self‐Organized Vascularized Human Liver Spheroids: Serum‐Free Culture Conditions and Use as Tissue Building Blocks

open access: yesSmall, EarlyView.
This approach addresses a major challenge in tissue engineering: creating larger, vascularized tissues. Microvascular networks in liver spheroids are developed through self‐organization mediated by mesenchymal stem cells. These spheroids are maintained in serum‐reduced or serum‐free medium and serve as building blocks to form planar tissue layers ...
Alina Filatova   +10 more
wiley   +1 more source

Theranostic π Electron‐Stabilized Polymeric Micelles for PET Imaging‐Guided Drug Delivery to Tumors

open access: yesSmall, EarlyView.
Cancer nanomedicine efficacy is limited by heterogeneous nanoparticle accumulation in tumors. Nuclear imaging offers non‐invasive, patient‐ and lesion‐specific visualization and quantification of nanoparticle uptake. We present a positron emission tomography (PET)‐imageable micelle platform for direct quantification of nanoparticle accumulation and ...
Alec Wang   +21 more
wiley   +1 more source

Multicellular origins of murine ovarian inflammaging. [PDF]

open access: yesCommun Biol
Galligos A   +7 more
europepmc   +1 more source

Active pH Modulation by Proton Channel‐Peptide Nucleic Acid Complex for Effective siRNA Endosomal Escape

open access: yesSmall, EarlyView.
A bioinspired siRNA nanocarrier is engineered by integrating an influenza A M2 proton channel with siRNA through a peptide nucleic acid linker on liposome surfaces. Active proton transport amplifies osmotic stress within endosomes, triggering membrane rupture and cytosolic release.
Seongmin Ga   +16 more
wiley   +1 more source

Reconciling Granular Hydrogel Microstructure and Mechanics via a Temporary Thermo‐Responsive and Cell‐Invadable Matrix

open access: yesSmall, EarlyView.
Thermo‐responsive granular hydrogels (TRGHs), composed of microparticles and an interstitial matrix, exhibit thermo‐responsive mechanical properties and allow cell infiltration. This system effectively addresses the conventional compromise between mechanical strength and porosity observed in granular hydrogels.
Jun Kim, Soyeon Kwon, Taimoor H. Qazi
wiley   +1 more source

Quantitative Imaging of Human Hemoglobin Binding to Staphylococcus aureus With Single‐Molecule Resolution

open access: yesSmall, EarlyView.
Single‐molecule localization microscopy is exploited to quantify the number of hemoglobin copies bound to specific receptors on S. aureus wall. This quantification supports the design of a photoactive derivative of hemoglobin able to photo‐inactivate S.
Pietro Delcanale   +10 more
wiley   +1 more source

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