Results 121 to 130 of about 59,203 (247)

The GBA1 p.E427K (p.E388K) Variant Is a Risk Factor for Synucleinopathies: A Meta‐Analysis

Movement Disorders, EarlyView.
Abstract Background Variants in GBA1 are important genetic risk factors for synucleinopathies, including Parkinson's disease (PD). Although several GBA1 variants are established risk or severity modifiers, the role of the p.E427K variant remains unclear.
Leah V. Chifamba, Sitki Cem Parlar, Emma N. Somerville, Lang Liu, Eric Yu, Farnaz Asayesh, Jamil Ahmad, Meron Teferra, Jennifer A. Ruskey, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Irina Miliukhina, Lior Greenbaum, Sharon Hassin‐Baer, Orly Goldstein, Mandy Radefeldt, Peter Bauer, Christian Beetz, Allison A. Dilliott, James C. Beck, Konstantin Senkevich, ROPAD Study Group, The Parkinson's Foundation PD GENEration Study, Christine Klein, Roy N. Alcalay, Ziv Gan‐Or   +30 more
wiley   +1 more source

The Effect of LRRK2 and GBA1 Mutations on Survival in Early‐ and Late‐Onset Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Mutations in the glucocerebrosidase 1 (GBA1) and leucine‐rich repeat kinase 2 (LRRK2) genes are associated with Parkinson's disease (PD) phenotype. Objective To asses the contribution of genetic status to long‐term survival of patients with PD.
Raz Rubin, Roy N. Alcalay, Nurit Omer, Orly Goldstein, Mali Gana Weisz, Anat Mirelman, Avner Thaler   +6 more
wiley   +1 more source

How to conduct research on overdiagnosis. A keynote paper from the EGPRN May 2016, Tel Aviv. [PDF]

Eur J Gen Pract, 2017
Brodersen J.
europepmc   +1 more source

Timing of Deep Brain Stimulation and Cognitive Trajectories in GBA1‐Associated Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Individuals with Parkinson's disease (PD) carrying GBA1 variants often develop advanced motor complications that prompt evaluation for deep brain stimulation (DBS). However, concerns about accelerated cognitive decline after DBS in GBA1 carriers complicate clinical decision making.
Evridiki Asimakidou, Micol Avenali, Jan O. Aasly, Mitra Afshari, Roy N. Alcalay, Sharlet Anderson, Carlo Alberto Artusi, Bryan Bernard, Marco Bozzali, Susan Bressman, Giovanna Calandra‐Buonaura, Francesco Cavallieri, Roberto Cilia, Jean‐Christoph Corvol, Antoniangela Cocco, Rob M.A. de Bie, Debra Ehrlich, Roberto Eleopra, Thomas Foltynie, Alessio Di Fonzo, Giulia Giannini, Christopher Goetz, Deborah Hall, Joohi Jimenez‐Shahed, Leonardo Lopiano, Vanessa Lythe, Maria Chiara Malaguti, Francesca Mameli, Graziella Mangone, Karen Marder, M. Maral Mouradian, Augusto Rini, Luisa Sambati, Rachel Saunders‐Pullman, Vicki Lynn Shanker, Francesca Spagnolo, Marie‐Laure Welter, Roberta Zangaglia, Gian Pal, Enza Maria Valente, PARKNET Study Group, Giada Cuconato, Ilaria Palmieri, Alberto Imarisio, Pierfrancesco Mitrotti, Francesca Valentino, Claudio Pacchetti, Gabriele Imbalzano, Claudia Ledda, Silvia Gallo, Pietro Cortelli, Luca Baldelli, Ilaria Cani, Raffaella Minardi, Valerio Carelli, Franco Valzania, Edoardo Monfrini, Filippo Cogiamanian, Chiara Longo, Fabiana Colucci, Luigi M. Romito, Marco Liccari   +61 more
wiley   +1 more source

Ongoing hepatitis A among men who have sex with men (MSM) linked to outbreaks in Europe in Tel Aviv area, Israel, December 2016 - June 2017. [PDF]

Euro Surveill, 2017
Gozlan Y, Bar-Or I, Rakovsky A, Savion M, Amitai Z, Sheffer R, Ceder N, Anis E, Grotto I, Mendelson E, Mor O.   +10 more
europepmc   +1 more source

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

Patients’ Anxiety Levels and Their Reactions Towards the Needed Adaptation of Policies in Methadone Maintenance Treatment Following the October 7th, 2023, Hamas Attack

Substance Abuse and Rehabilitation
Anat Sason,1 Miriam Adelson,1 David Potik,1,2 Shaul Schreiber,1,3,4 Einat Peles1,3,4 1Dr. Miriam & Sheldon G. Adelson Clinic for Drug Abuse, Treatment & Research, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel; 2Department of Criminology, Bar-Ilan ...
Sason A, Adelson M, Potik D, Schreiber S, Peles E   +4 more
doaj  

A Modular Hybrid Framework for CEST MRI Development and Clinical Translation Using pTx‐Pulseq Preparation With Open‐ and Closed‐Source Readouts and ONNX Mapping

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Chemical exchange saturation transfer (CEST) MRI offers unique metabolic insights for imaging of cancer, stroke, or neurodegeneration. However, the rapid expansion of CEST preparation schemes and evaluation techniques creates a bottleneck; novel methods often remain complex prototypes requiring offline processing, preventing clinical ...
Martin Freudensprung, Junaid R. Rajput, Patrick Liebig, Simon Weinmüller, Ludwig Singer, Nikita Vladimirov, Or Perlman, Armin Michael Nagel, Arnd Doerfler, Moritz Zaiss   +9 more
wiley   +1 more source

Are Age and Voided Volume Sufficient to Predict Detrusor Underactivity in Women? An External Validation Study

Neurourology and Urodynamics, EarlyView.
ABSTRACT Purpose Detrusor underactivity (DU) is a significant cause of female lower urinary tract symptoms. We aimed to externally validate a non‐invasive prediction model using age and voided volume (VV) in a tertiary center cohort. Methods This retrospective study included 450 consecutive women who underwent uroflowmetry and subsequently multichannel
Netanel Levin, Elad Yosef, Rony Vainrib, Matan Linevitz, Yanay Shaked, Amos Neheman, Michael Vainrib, Omri Schwarztuch Gildor   +7 more
wiley   +1 more source