Results 161 to 170 of about 88,563 (282)

Prevalence of Systemic Comorbidities and Ocular Complications in Patients With Bilateral Retinal Telangiectasia. [PDF]

J Vitreoretin Dis
Zhao CS, Do DV, Sanislo SR, Ludwig C, Rahimy E, Mruthyunjaya P, Wai KM.   +6 more
europepmc   +1 more source

RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation

Photochemistry and Photobiology, EarlyView.
UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan, Angitha Nair, M. Alexandra Carpenter, Michael G. Kemp   +3 more
wiley   +1 more source

Characterizing Self‐Reported Daily Diary Epistaxis Measures in Hereditary Hemorrhagic Telangiectasia

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 2, April 2026.
This study investigates the use of daily self‐reported nosebleed diaries to measure epistaxis severity in patients with Hereditary Hemorrhagic Telangiectasia (HHT), minimizing recall bias. Two novel metrics—PRO‐CB (cumulative bleeding duration) and PRO‐CGB (gushing bleeding duration)—are introduced and compared with the traditional Epistaxis Severity ...
C. M. Tarulli, X. Ma, A. M. Bayoumi, A. Patel, N. T. Vozoris, J. M. Lee, M. E. Faughnan   +6 more
wiley   +1 more source

Unmasking a Rare Genetic Puzzle: Hereditary Hemorrhagic Telangiectasia in a Black Kenyan Woman: A Case Report. [PDF]

Case Rep Gastrointest Med
Otom L, Panwar P, Kaittany F, Lomatayo BC.   +3 more
europepmc   +1 more source

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, Volume 183, Issue 8, Page 1640-1652, April 2026.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

Beyond epistaxis: cascade screening and presymptomatic treatment of hereditary hemorrhagic telangiectasia. [PDF]

BMC Pediatr
Ang CX, Chin HL, Tan SZT.
europepmc   +1 more source

A phase 1 study of berzosertib (M6620, VX‐970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950)

Cancer, Volume 132, Issue 6, 15 March 2026.
ABSTRACT Background Ataxia telangiectasia Rad3‐related (ATR) protein kinase regulates DNA damage response and is essential for tumor cell survival. Preclinically, ATR inhibition can sensitize tumor cells to radiation and chemotherapy. The authors conducted a phase 1 trial of berzosertib, a selective ATR inhibitor, in combination with definitive ...
Aarti Bhatia, Zhengjia Chen, Yuji Zhang, Justine Yang Bruce, Susanne Arnold, Varinder Kaur, Jonathan W. Riess, Moon Fenton, Barbara Burtness, Nabil F. Saba, Harold Tara, Conor E. Steuer, Dong M. Shin, Garrett Wasp, Thomas H. Davis, Malini Patel, John C. Schmitz, Priyanka Bhateja, Virginia Diavolitsis, Dan P. Zandberg, Darrion L. Mitchell, Brian F. Kiesel, Charles Kunos, Steven D. Gore, Michael Carducci, Jan H. Beumer, Taofeek K. Owonikoko   +26 more
wiley   +1 more source

Imperatorin Mitigates Rosacea‐Like Inflammation by Modulating the Crosstalk Between JNK1 and STAT1

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
IMP treatment disrupts the interaction between JNK1 and STAT1, thereby attenuating STAT1 activity. This interference subsequently diminishes the phosphorylation and nuclear translocation of STAT1, which ultimately results in a reduced production of inflammatory cytokines and chemokines.
Xiaoxue Wang, Zexin Zhu
wiley   +1 more source

Cerebrovascular Malformations Associated With Hereditary Hemorrhagic Telangiectasia and HHT-Like Syndromes: A Comparative Overview. [PDF]

Eur J Neurol
Palermo M, Sturiale CL.
europepmc   +1 more source

Hæmorrhagic Telangiectasia [PDF]

Proceedings of the Royal Society of Medicine, 1945
openaire   +2 more sources