Results 171 to 180 of about 88,563 (282)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, Volume 20, Issue 3, Page 668-687, March 2026.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Osteolysis After Interphalangeal Joint Arthrodesis in Systemic Sclerosis: A Case Series. [PDF]

J Rheumatol
Mathias KR, Grandison J, Lifchez SD, Wigley F.   +3 more
europepmc   +1 more source

Transition From Juvenile Dermatomyositis to Spondyloarthritis: A Novel Overlapping Inflammatory Phenotype

ACR Open Rheumatology, Volume 8, Issue 3, March 2026.
Objective Juvenile dermatomyositis (JDM) is a rare childhood inflammatory myopathy, whereas spondyloarthritis (SpA) is an inflammatory arthropathy characterized by enthesitis and peripheral or axial involvement. We describe a series of patients diagnosed with JDM in childhood who later fulfilled classification criteria for SpA, a sequential phenotype ...
Austen Grooms, Ioannis Karageorgiou, Kerry Mychaliska, James Birmingham   +3 more
wiley   +1 more source

Getting a Leg Up on Assessment of Cutis Marmorata Telangiectatica Congenita and Leg Length Discrepancy

Pediatric Dermatology, EarlyView.
Ou Jia Emilie Wang, Joseph M. Lam
wiley   +1 more source

Distinct by Design: Unraveling the Unique Clinical and Transcriptomic Identity of Juvenile Scleromyositis Overlap Compared to Juvenile Systemic Sclerosis and Juvenile Dermatomyositis: Implications for Care and Pathogenesis

ACR Open Rheumatology, Volume 8, Issue 3, March 2026.
Objective To characterize clinical and transcriptomic differences in juvenile scleromyositis overlap (jOverlap) compared to juvenile systemic sclerosis (jSSc) and juvenile dermatomyositis (JDM), focusing on autoantibody profiles, organ involvement, treatment, and peripheral blood gene expression.
Amanda D. Robinson, Clare E. Pain, Gabrielle A. Morgan, Anwesha Sanyal, Srilakshmi Chaparala, Lauren M. Pachman, Kathryn S. Torok   +6 more
wiley   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

A 10-Year-Old Boy With Ataxia-Telangiectasia: A Rare Case Report From Yemen. [PDF]

Clin Med Insights Case Rep
Muneer M, Al-Kubati A, Al-Ghashm A, Albaseer L, Sleiay B, Alkubati A, Shallan M, Alhofari BM, Salama Daas L.   +8 more
europepmc   +1 more source

Inhibition of Autophagy Reveals ATR Protein Kinase as a Key Mediator of Cisplatin Sensitivity in Osteosarcoma

Cancer Medicine, Volume 15, Issue 3, March 2026.
ATRi blocks phosphorylation of p53 (S15) and enhances cell death in cisplatin‐treated osteosarcoma cells. ABSTRACT Introduction Osteosarcoma (OS) is the most common primary malignant bone tumor. Although the introduction of chemotherapy has improved the survival rate of OS patients, chemoresistance remains a major clinical problem underlying poor ...
Janice S. Pereira, Gabriel Rosa, Aine Pears, Beata Burczynska, Britta Stordal, Scott J. Roberts, Helen C. Roberts   +6 more
wiley   +1 more source

Breast Fibromatosis in a Patient With a History of Treated Breast Cancer: A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Desmoid tumors are benign mesenchymal neoplasms that originate from muscular fasciae and aponeuroses. Breast involvement is exceptionally rare, accounting for less than 0.2% of all breast tumors. A 41‐year‐old woman with a history of right‐sided invasive ductal carcinoma (IDC) diagnosed in 2022 underwent breast‐conserving surgery (BCS) and ...
Saba Ebrahimian, Sakineh Soleimani Varaki, Faezeh Zabihi   +2 more
wiley   +1 more source

A 45-Year-Old Woman With Hereditary Hemorrhagic Telangiectasia and Persistent Exertional Dyspnea and Peripheral Edema. [PDF]

Chest
Triantafyllidi H, Birmpa D, Fambri A, Benas D, Montani D.   +4 more
europepmc   +1 more source