Results 41 to 50 of about 61,429 (293)

Osler-Weber-Rendu disease: A rare cause of recurrent hemoptysis

Lung India, 2016
Osler-Weber-Rendu disease, also known as hereditary hemorrhagic telangiectasia, is a rare autosomal dominant condition causing systemic fibrovascular dysplasia. It has an incidence of 1-2/100,000. Phenotypic variation is extreme ranging from asymptomatic
Amir M Khoja, Rahul K Jalan, Dheeraj L Jain, Omkar V Kajale   +3 more
doaj   +1 more source

Angiogenesis, hereditary hemorrhagic telangiectasia and COVID-19

, 2020
Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal-dominant disease characterized by pathologic angiogenesis that provokes vascular overgrowth.
López-Wolf, Daniel, Riera-Mestre, Antoni, Moreno, Manuela, Del Castillo, Raul, Iriarte, Adriana   +4 more
core   +1 more source

Generalized essential telangiectasia [PDF]

, 2018
The pathophysiology of generalized essential telangiectasia is not well understood. Generalized essential telangiectasia is an uncommon disorder in which widespread telangiectasias of unknown cause develop without associated systemic or antecedent ...
Femia, Alisa N, Wiznia, Lauren E, Steuer, Alexa B, Meehan, Shane A, Penn, Lauren A   +4 more
core   +1 more source

Coats disease in 351 eyes: Analysis of features and outcomes over 45 years (by decade) at a single center

Indian Journal of Ophthalmology, 2019
Purpose: To assess features and outcomes of Coats disease over 5-decades. Methods: Retrospective review of Coats disease patients at a single center. Features and outcomes were compared based on decade of presentation.
Carol L Shields, Sanika Udyaver, Lauren A Dalvin, Li–Anne S Lim, Hatice T Atalay, Chloe T L Khoo, Mehdi Mazloumi, Jerry A Shields   +7 more
doaj   +1 more source

Conjunctival Telangiectasia in a Patient with Ataxia Telangiectasia: A Case Report

, 2012
The purpose of this paper is to report a 7-year-old patient who developed bilateral conjunctival hyperemia while being under treatment of pneumonia in Pediatric Infectious Diseases Clinic at Sisli Etfal Training and Research Hospital.
Dilek Güven, Özge Pınar Akarsu, Cemile Üçgül Atılgan   +2 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transdermal laser for facial vascular lesions: a single center experience [PDF]

Jornal Vascular Brasileiro
Background Facial vascular lesions are a common situation in medical practice and can cause cosmetic concerns for patients. Objectives To evaluate the results of facial telangiectasia treatment using the Nd:YAG 1064nm transdermal laser.
Felipe Coelho Neto, Fernando Tres Silveira, Paulo Roberto Bignardi, Sergio Quilici Belczak, Walter Junior Boim de Araujo, Rodrigo Gomes de Oliveira   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source