Results 81 to 90 of about 7,212 (260)
Revista Habanera de Ciencias Médicas, 2009 La telangiectasia hemorrágica hereditaria es un trastorno autosómico dominante de la pared de los vasos sanguíneos que se presentan tortuosos y dilatados.
Mildrey Jiménez López +2 more
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Advances in Immunological Combination Therapy for Colorectal Cancer
iMetaMed, EarlyView.Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu +7 more
wiley +1 more source
iMetaMed, EarlyView.Applying single‐cell RNA‐seq techniques to large‐scale clinical phenotypic data enables the discovery of differential disease progression trajectories and the construction of data‐driven progression scores. These can then be integrated into precision medicine studies to investigate the drivers of patient‐specific disease outcomes. ABSTRACT We propose a
Christian Anderson +11 more
wiley +1 more source
Cutaneous manifestations of ataxia telangiectasia: A systematic review
JAAD ReviewsAtaxia telangiectasia (A-T) is a rare neurocutaneous disorder characterized by cerebellar impairment, immunodeficiency, and telangiectasias. This review sought to assess all reported cutaneous findings observed in individuals with A-T.
Jenny Lai, PhD +3 more
doaj +1 more source
ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential
iNew Medicine, EarlyView.ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang +5 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.This graphical abstract illustrates the dynamic bidirectional crosstalk between microRNA biogenesis and autophagy, which serves as a critical regulatory axis in cardiovascular homeostasis. We highlight how specific miRNAs modulate autophagic flux to mitigate vascular inflammation and plaque instability, while concurrently, the autophagic machinery ...
Sepehr Ebrahimi‐Dehkordi +11 more
wiley +1 more source
The Association of Telangiectasias with Other Peripheral Vascular Lesions of Systemic Sclerosis
Clinical, Cosmetic and Investigational DermatologyCarmen Bobeica,1,* Elena Niculet,2,3,* Carmina Liana Musat,2,* Lina Iancu,4 Mihaela Craescu,2,3 Andreea Mioara Luca,5 Bogdan Ioan Stefanescu,6 Emma Gheorghe,7 Mihaela Debita,8 Claudiu-Ionut Vasile,8 Gabriela Balan,8– 10 Camelia Busila,8 Alin ...
Bobeica C +12 more
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Peliosis hepática: presentación de un caso con correlación radiológica y patológica
Anales de Radiología, MéxicoLa peliosis hepática es un trastorno benigno poco común caracterizado por la presencia de dilatación y ocupación por sangre de los sinusoides hepáticos.
Carmen K. Márquez-Lozano +4 more
doaj +1 more source
Journal of Pediatric Gastroenterology and Nutrition, EarlyView.Abstract Objectives Hereditary polyposis syndromes in children are rare, heterogeneous disorders associated with significant morbidity and long‐term risk of malignancy. Current data on their presentation, management, and outcomes in pediatric populations remain limited.
Shlomi Cohen +9 more
wiley +1 more source