Results 131 to 140 of about 113,241 (315)

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

open access: yesAdvanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu   +9 more
wiley   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

open access: yesAdvanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu   +20 more
wiley   +1 more source

Television and Divorce: Evidence from Brazilian Novelas [PDF]

open access: yes
This paper studies the link between television and divorce in Brazil by exploiting variation in the timing of availability of the signal of Rede Globo—the network that had a virtual monopoly on telenovelas in the country—across municipal areas.
Eliana La Ferrara, Alberto Chong
core  

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

open access: yesAdvanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang   +12 more
wiley   +1 more source

Media Analysis Report - Journalism in multicultural Australia - Television News 2005

open access: yes, 2006
During the first half of 2001 a group of researchers at Murdoch University joined with Norm Taylor, former head of News and Current Affairs at the ABC, to create a methodology for analysing the shape and substance of television news.
Tapsall, S., Phillips, G.
core  

Television viewing time and risk of incident obesity and central obesity: the English longitudinal study of ageing

open access: yes, 2015
Background Research suggests television viewing time may be associated with incident obesity and central obesity in young adults. No study has investigated these associations in older English adults.
Fisher, A   +5 more
core   +1 more source

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

open access: yesAdvanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai   +11 more
wiley   +1 more source

Co-constructions of gender and ethnicity in New Zealand television advertising

open access: yes, 2011
This paper reports key findings from a content analysis of gender and ethnic depictions in a sample of 2,120 New Zealand prime-time television advertisements screened in 2006.
Michelle, Carolyn, Carolyn Michelle
core   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li   +15 more
wiley   +1 more source

Old Wine in New Bottles. Narrative complexity in the dawn of Netflix Originals (2013-2017)

open access: yesCommunication & Society (Formerly Comunicación y Sociedad)
This article explores how the first five years of Netflix Originals dramatic storytelling fit the “Complex TV” label that Mittell defined, with its innovative season-drop delivery strategy. We focus on one narratological device: the delimited flashback,
José-Antonio Planes, Alberto-N. García
doaj   +1 more source

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