Results 161 to 170 of about 18,522,447 (385)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
An empirically derived inorganic sea spray source function incorporating sea surface temperature [PDF]
, 2015 Matthew Salter +7 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Progress in Earth and Planetary ScienceMany species establish symbiotic partnerships with different organisms to benefit energetically from living together to fit into environments, and such symbiosis is frequently found in the modern ocean as well as throughout Earth’s history.
Jincen Li +3 more
doaj +1 more source
Daily High-Resolution-Blended Analyses for Sea Surface Temperature
, 2007 R. Reynolds +5 more
semanticscholar +1 more source
Nonlinear temperature effects indicate severe damages to U.S. crop yields under climate change
Proceedings of the National Academy of Sciences of the United States of America, 2009 W. Schlenker, M. Roberts
semanticscholar +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Phonon Angular Momentum Induced by the Temperature Gradient [PDF]
, 2018 Masato Hamada +3 more
openalex +1 more source
The Arctic oscillation signature in the wintertime geopotential height and temperature fields
, 1998 D. Thompson, J. Wallace
semanticscholar +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source