Results 321 to 330 of about 18,071,019 (382)

Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell‐Based Model

Advanced Biology, EarlyView.
This study develops a tissue‐engineered model of the atherosclerotic cap using human mesenchymal stromal cells (MSCs). After 2 weeks of culture to produce a collagenous matrix, a mineralizing medium induces microcalcifications over 4 weeks. These constructs, imaged with second harmonic generation microscopy, lead to reduced ultimate stress at rupture ...
Imke L. Jansen, Deniz Şahin, Frank J.H. Gijsen, Eric Farrell, Kim van der Heiden   +4 more
wiley   +1 more source

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

Advanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso, Sara Carpi, Laura Colagiorgio, Miriam De Sarlo, Mariacristina Gagliardi, Marco Cecchini   +5 more
wiley   +1 more source

Experimental and numerical study on FRP-rehabilitated RC beam-column joints at high temperature with artificial neural network. [PDF]

Sci Rep
Prakash RS, Parthasarathi N.
europepmc   +1 more source

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

High precision integrated sensors for multi-parameter online monitoring in salt spray environments. [PDF]

Microsyst Nanoeng
Cao R, Yin J, Tong H, Lu S, Li S, Gao W, Zou J, Jin Q.   +7 more
europepmc   +1 more source

Studies of magnetic properties of EuSnP single crystals. [PDF]

Sci Rep
Podgórska K, Komędera K, Przewoźnik J, Gondek Ł, Kapusta C, Tabiś W, Babij M, Tran LM, Rybicki D.   +8 more
europepmc   +1 more source

Experimental study of strength degradation in fractured surrounding rock of deep high-temperature tunnels. [PDF]

Sci Rep
Jiang H, Zhang J, Wei G, Yu T.
europepmc   +1 more source