Results 91 to 100 of about 286,151 (306)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Improvements to the AERIoe Thermodynamic Profile Retrieval Algorithm

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2019
Temperature and humidity profiles in the atmospheric boundary layer (i.e., from the surface to 3 km) can be retrieved from ground-based spectral infrared observations made by the atmospheric emitted radiance interferometer (AERI) at high temporal and ...
David D. Turner, W. Greg Blumberg
doaj   +1 more source

Temperature and humidity profile retrievals from ground-based microwave radiometers during TUC

Meteorologische Zeitschrift, 2006
Thermodynamic atmospheric profiles have been retrieved from ground-based microwave radiometers during the Temperature, hUmidity, and Cloud (TUC) profiling campaign. A variety of inversion methods is presented, in terms of requirements, advantages, and limitations.
Domenico Cimini, Tim J. Hewison, Lorenz Martin, Jurgen Guldner, Catherine Gaffard, MARZANO, FRANK SILVIO   +5 more
openaire   +4 more sources

Increased insolation threshold for runaway greenhouse processes on Earth like planets

, 2013
Because the solar luminosity increases over geological timescales, Earth climate is expected to warm, increasing water evaporation which, in turn, enhances the atmospheric greenhouse effect.
A Arking, A Borysow, A Bucholtz, Alizée Pottier, AP Ingersoll, B Charnay, B Van Leer, Benjamin Charnay, BJ Soden, C Goldblatt, C Goldblatt, C Richard, DMW Frierson, DO Gough, E Wolf, F Forget, F Forget, F Hourdin, F Selsis, Francois Forget, G Le Hir, GC Simpson, GL Mellor, H Le Treut, J Leconte, J Yang, JE Hansen, JF Kasting, JF Kasting, JF Kasting, Jérémy Leconte, LS Rothman, M Ishiwatari, M Komabayashi, O Boucher, OB Toon, R Wordsworth, R Wordsworth, RD Wordsworth, RK Kopparapu, Robin Wordsworth, RT Pierrehumbert, RT Pierrehumbert, RT Pierrehumbert, S Clough, S Manabe, S Nakajima, SC Sherwood, V Ramanathan, Y Abe   +49 more
core   +4 more sources

On the complexity of the boundary layer structure and aerosol vertical distribution in the coastal Mediterranean regions: A case study [PDF]

, 2015
The planetary boundary layer structure in the coastal areas, and particularly in complex orography regions such as the Mediterranean, is extremely intricate.
Cacciani, Marco, Cremona, Giuseppe, Iannarelli, Anna Maria, Junkermann, Wolfgang, Meloni, Daniela, Pace, Giandomenico, Sarra, Alcide Di, Vitali, Lina, Zanini, Gabriele   +8 more
core   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Algorithm Development of Temperature and Humidity Profile Retrievals for Long-Term HIRS Observations

Remote Sensing, 2016
A project for deriving temperature and humidity profiles from High-resolution Infrared Radiation Sounder (HIRS) observations is underway to build a long-term dataset for climate applications.
Lei Shi, Jessica L. Matthews, Shu-peng Ho, Qiong Yang, John J. Bates   +4 more
doaj   +1 more source

NASA Langley Research Center National Aero-Space Plane Mission simulation profile sets [PDF]

To provide information on the potential for long life service of oxidation resistant carbon-carbon (ORCC) materials in the National Aero-Space Plane (NASP) airframe environment, NASP ascent, entry, and cruise trajectories were analytically flown ...
Bresina, John J., Ohlhorst, Craig W., Vaughn, Wallace L.   +2 more
core   +1 more source

Warming the early Earth - CO2 reconsidered

, 2008
Despite a fainter Sun, the surface of the early Earth was mostly ice-free. Proposed solutions to this so-called "faint young Sun problem" have usually involved higher amounts of greenhouse gases than present in the modern-day atmosphere.
Barbara Stracke, Beate Patzer, Brown, Caldeira, Cess, Colaprete, Franz Schreier, Goody, Goody, Gough, Grenfell, Grenfell, Heike Rauer, Hessler, Ingersoll, J. Lee Grenfell, Jenkins, Kasting, Kasting, Kasting, Kasting, Kasting, Kasting, Kasting, Knauth, Lacis, Manabe, Minton, Mischna, Mlawer, Mojzsis, Pascal Hedelt, Pavlov, Pavlov, Pavlov, Philip von Paris, Robert, Rosing, Rothman, Rye, Sagan, Sagan, Schreier, Segura, Segura, Shaviv, Shields, Sleep, Thomas Trautmann, Toon, Toth, Towe, Vardavas, Vardavas, West, Wiscombe   +55 more
core   +1 more source

Atmospheric teleconnection mechanisms of extratropical North Atlantic SST influence on Sahel rainfall [PDF]

, 2014
Extratropical North Atlantic cooling has been tied to droughts over the Sahel in both paleoclimate observations and modeling studies. This study, which uses an atmospheric general circulation model (GCM) coupled to a slab ocean model that simulates this ...
Chiang, JCH, Chou, C, Liu, Y, Patricola, CM   +3 more
core   +1 more source