Results 101 to 110 of about 286,151 (306)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Joint retrieval of atmospheric temperature and humidity profiles using spaceborne hyperspectral microwave radiometer

GIScience & Remote Sensing
This paper explores the performance advantages of spaceborne hyperspectral microwave radiometers for jointly retrieving atmospheric temperature and humidity profiles under clear-sky conditions.
Chao Zhang, Jieying He, Gang Ma, Shengwei Zhang, Minjie Zhang   +4 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Geometric Factor Correction Algorithm Based on Temperature and Humidity Profile Lidar

Remote Sensing
Due to the influence of geometric factors, the temperature and humidity profile of lidar’s near-field signal was warped when sensing the air environment. In order to perform geometric factor correction on near-field signals, this article proposes different correction solutions for the Mie and Raman scattering channels.
Bowen Zhang, Guangqiang Fan, Tianshu Zhang   +2 more
openaire   +2 more sources

A scheme for computing surface layer turbulent fluxes from mean flow surface observations [PDF]

A physical model and computational scheme are developed for generating turbulent surface stress, sensible heat flux and humidity flux from mean velocity, temperature and humidity at some fixed height in the atmospheric surface layer, where conditions at ...
Hoffert, M. I., Storch, J.
core   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Influence of Atmospheric Slant Path on Geostationary Hyperspectral Infrared Sounder Radiance Simulations

Geophysical Research Letters
Accurately simulating a geostationary hyperspectral infrared sounder is critical for quantitative applications. Traditional radiation simulations of such instruments often overlook the influence of slant observation geometry by using vertical profile ...
Pengyun Huang, Jun Li, Min Min, Zhenglong Li, Di Di, Valentine Anantharaj, Myoung‐Hwan Ahn   +6 more
doaj   +1 more source

Molecfit: A general tool for telluric absorption correction. I. Method and application to ESO instruments

, 2015
Context: The interaction of the light from astronomical objects with the constituents of the Earth's atmosphere leads to the formation of telluric absorption lines in ground-based collected spectra.
Ballester, P., Barden, M., Gallenne, A., Horst, H., Jones, A. M., Kausch, W., Kimeswenger, S., Noll, S., Sana, H., Smette, A., Szyszka, C., Taylor, J., Vinther, J.   +12 more
core   +2 more sources