Results 51 to 60 of about 121,277 (302)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Network balance via CRY signalling controls the Arabidopsis circadian clock over ambient temperatures [PDF]

, 2013
Circadian clocks exhibit ‘temperature compensation', meaning that they show only small changes in period over a broad temperature range. Several clock genes have been implicated in the temperature-dependent control of period in Arabidopsis.
Julia Foreman, Rand, DA, Hall, AJ, Penfield, Steven, Karen J Halliday, Costa, Maria J. (Maria João), Gould, Peter, Macgregor, D, Rose, K, Halliday, Karen J., Dana MacGregor, Domijan, Mirela, Anthony J W Hall, Hall, Anthony J.W., Mirela Domijan, Foreman, Julia, Gould, Peter D., Peter D Gould, Rand, David A., MacGregor, Dana, Ken Rose, Halliday, KJ, Bärbel Finkenstädt, Millar, Andrew J., Andrew J Millar, Steven Penfield, David A Rand, Griffiths, Jayne, Hall, Anthony J W, Domija, Mirela, Rand, D. A. (David A.), Domijan, M, Hall, Anthony J. W., Costa, Maria, Rand, David A, Gould, Peter D, Jayne Griffiths, Griffiths, J, Maria Costa, Penfield, S, Halliday, Karen J, Ugarte, N, Finkenstädt, Bärbel, Finkenstädt, B, Nicolas Ugarte, Millar, Andrew J; id_orcid, Millar, A. J. (Andrew J.), Ugarte, Nicolas, Rose, Ken, Foreman, J   +49 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

An in-line photonic crystal fibre-based Mach-Zehnder interferometer with temperature compensation

, 2014
An in-line photonic crystal fibre-based Mach-Zehnder interferometer (PCF-MZI) with temperature compensation has been proposed and experimentally demonstrated.
Jiang Y, Ding WH, Gao R, Liu YW(刘曰武), Ding, WH (reprint author), Beijing Inst Technol, Sch Optoelect, Beijing 100081, Peoples R China., Wang Z   +5 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

RESEARCH ON SENSOR TEMPERATURE COMPENSATION SYSTEM BASED ON IMPROVED RBF NEURAL NETWORK

Jixie qiangdu, 2016
Considering the current temperature compensation method is used to establish the temperature compensation model using intelligent algorithm,and use swarm intelligent optimization algorithm to optimize and improve the compensation precision,has good ...
SONG RuiJuan
doaj  

Temperature Drift Compensation of Eddy Current Sensor under High Temperature Environment

E3S Web of Conferences, 2018
Eddy current sensor is an sensor based on eddy current effect. In practical engineering applications, the ambient temperature of eddy current sensor may be up to 135 ℃.
He Ping, Ma YunKai, Chen Hui
doaj   +1 more source

Research on All-Fiber Dual-Modulation Optic Current Sensor Based on Real-Time Temperature Compensation

IEEE Photonics Journal, 2022
We present a method to simultaneously measure the temperature and electric current, which can be applied for the all-fiber optic current sensor (AFOCS) temperature compensation.
Jianhua Wu, Xiaofeng Zhang, Liang Chen, Benxiang Wu, Cheng Peng   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Improving the Consistency of Injection Molding Products by Intelligent Temperature Compensation Control

Advances in Polymer Technology, 2019
Temperature stability is critical to the consistency of product quality in the injection molding process, and it is very necessary to improve the temperature control accuracy under dynamic conditions. However, due to the large time delay, strong coupling,
Yufei Ruan, Huang Gao, Dequn Li
doaj   +1 more source