Results 81 to 90 of about 2,279,786 (296)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Temperature Profile for the Innovative Design of the Perforated Fin [PDF]

, 2016
The development of the perforated fin had proposed in many studies to enhance the heat transfer from electronic pieces. This paper presents a novel derivative method to find the temperature distribution of the new design (inclined perforated) of the pin ...
Al-Saddy, H. (Hisham), Soylemez, M. (Mehmet)   +1 more
core  

Reversal-free CaIIH profiles: a challenge for solar chromosphere modeling in quiet inter-network

, 2008
We study chromospheric emission to understand the temperature stratification in the solar chromosphere. We observed the intensity profile of the CaIIH line in a quiet Sun region close to the disk center at the German Vacuum Tower Telescope.
Avrett, Ayres, Ayres, Balasubramaniam, Beck, Beck, C. Beck, Carlsson, Carlsson, Cram, Fontenla, Fontenla, Grossman-Doerth, Heasley, Holweger, J. H. M. J. Bruls, Judge, Kalkofen, Linsky, Lites, Lites, R. Rezaei, R. Schlichenmaier, Rammacher, Rezaei, Rezaei, Schmidt, Shine, Solanki, Stenflo, Uitenbroek, Uitenbroek, Uitenbroek, Vernazza, W. Kalkofen, W. Schmidt, Wedemeyer-Böhm, Wedemeyer-Böhm, Wöger   +38 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Temperature profiles in microwave heated solid foods of slab geometry: Influence of process parameters

Czech Journal of Food Sciences, 2001
A simple 1-D mathematical model for prediction of local temperatures in a layer of solid material during microwave heating (Houšová et al. 1998) and a sensitivity analysis were used to evaluate the influence of process and material parameters on vertical
J. Houšová, K. Hoke
doaj   +1 more source

Daytime Temperature Profiles

Journal of the Atmospheric Sciences, 1966
Abstract An equation for the daytime lapse rate of temperature as a function of z/L is derived assuming the lapse rate varies as z−⅔ in very light winds. This variation is presumed to result from the geometry of buoyant plumes. The equation, which agrees very well with some data taken by Dyer, predicts a maximum value for the lapse rate at a fixed ...
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A novel method for computation of temperature profile of turbine disk

Journal of Thermal Science and Technology, 2017
A novel temperature computation method of turbine disk is proposed according to theoretical analysis, where the coupling analysis of the outer surface in disk and fluid relative to this outer surface was carried out, instead of the segregation condition (
Weilin DONG, Suofang WANG, Jiajia NIU
doaj   +1 more source

Suzaku measurement of Abell 2204's intracluster gas temperature profile out to 1800 kpc

, 2009
Context: Measurements of intracluster gas temperatures out to large radii are important for the use of clusters for precision cosmology and for studies of cluster physics.
A. Hoshino, Allen, Anders, Arnaud, Clowe, D. S. Hudson, De Grandi, Evrard, Frenk, Fujimoto, Fujita, Henley, Hudson, Irwin, Irwin, Ishisaki, K. Sato, Kalberla, Kotov, Kushino, Leccardi, Markevitch, Markevitch, Mitsuda, N. Ota, Piffaretti, Pratt, Reiprich, Revnivtsev, Roncarelli, Sanders, Sanders, Sato, Schuecker, Snowden, Solovyeva, Struble, T. H. Reiprich, T. Ohashi, Tawa, Vecchi, Vikhlinin, White, Y. Fujita, Y. Ishisaki, Y.-Y. Zhang, Zhang, Zhang   +47 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source