Results 91 to 100 of about 358,253 (307)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

3-Dimensional Computational Analysis Of Fluid Flow Around Micro Flow Sensor At Different Positions And Pillar Arrangement Tony Tan Hin Jooqa297. [T161 2008 F Rb] [PDF]

, 2008
Analisis pengaliran bendalir mengelilingi pengesan mikro telah dipamerkan dalam penyelidikan ini. Dalam analisis tersebut, pengesan mikro dianggap dipasangkan dalam saluran berbentuk segi empat tepat.
Tan, Tony Hin Joo
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Temperature Drift Compensation of Eddy Current Sensor under High Temperature Environment

E3S Web of Conferences, 2018
Eddy current sensor is an sensor based on eddy current effect. In practical engineering applications, the ambient temperature of eddy current sensor may be up to 135 ℃.
He Ping, Ma YunKai, Chen Hui
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Dielectric Wireless Passive Temperature Sensor

Journal of Sensor and Actuator Networks
Resonators are passive components that respond to an excitation signal by oscillating at their natural frequency with an exponentially decreasing amplitude.
Taimur Aftab, Shah Hussain, Leonhard M. Reindl, Stefan Johann Rupitsch   +3 more
doaj   +1 more source

An Annular Mechanical Temperature Compensation Structure for Gas-Sealed Capacitive Pressure Sensor

Sensors, 2012
A novel gas-sealed capacitive pressure sensor with a temperature compensation structure is reported. The pressure sensor is sealed by Au-Au diffusion bonding under a nitrogen ambient with a pressure of 100 kPa and integrated with a platinum resistor ...
Kohei Higuchi, Yonggang Jiang, Kazusuke Maenaka, Hidekuni Takao, Xiuchun Hao   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Fabrication of high temperature surface acoustic wave devices for sensor applications

, 2005
Surface acoustic devices have been shown to be suitable not only for signal processing but also for sensor applications. In this paper high temperature surface acoustic wave devices based on gallium orthophosphate have been fabricated, using a lift-off ...
Hamidon, MN, Krempl, P, Binhack, M, Krispel, F, Skarda, V, White, NM, Buff, W   +6 more
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