Advanced Science, EarlyView.A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu +7 more
wiley +1 more source
Drug Repurposing Uncovers New Chemical Scaffolds as Potent Urease Inhibitors: A Comprehensive Computational Study. [PDF]
Int J Mol SciRíos-Rozas SE +11 more
europepmc +1 more source
Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency
Advanced Science, EarlyView.How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen +10 more
wiley +1 more source
Effect of Tempering Temperature on Microstructural Evolution and Mechanical Properties of Cr-Ni-Mo-V Steel for Pressure Vessel Applications. [PDF]
Materials (Basel)Liang E +6 more
europepmc +1 more source
A Multiscale Mechanistic Framework for Polydopamine Dyeing in Ultrablack Wool Textiles
Advanced Science, EarlyView.Ultrablack photonic textiles are enabled through polydopamine (PDA) dyeing, which is governed by the interplay of PDA chemistry, wool surface topology and chemistry, and hierarchical fiber–yarn–fabric architecture. Fabric architecture emerges as a primary and previously underappreciated design lever for wide‐angle optical performance.
Hansadi Jayamaha +4 more
wiley +1 more source
Influence of Mo and Ni Alloying on Recrystallization Kinetics and Phase Transformation in Quenched and Tempered Thick Steel Plates. [PDF]
Materials (Basel)Azpeitia X +5 more
europepmc +1 more source
Advanced Science, EarlyView.This study elucidates the microstructural evolution at the material interface of Ni‐plated plain‐weave carbon fiber fabric following vacuum heat treatment at 500°C–900°C under different current densities, as well as the mechanism underlying the synergistic enhancement of electromagnetic shielding and ductility.
Wei Cheng +7 more
wiley +1 more source
Developing NiAl-Strengthened ULCB Steels by Controlling Nanoscale Precipitation and Reversed Austenite. [PDF]
Materials (Basel)Guo J, Chai X, Gong S, Wang Z, Pan T.
europepmc +1 more source
Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy
Advanced Science, EarlyView.ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin +8 more
wiley +1 more source