Results 81 to 90 of about 170,600 (365)
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Teshugang, 2019 The microstructure, impact performance and fracture morphology of 42CrMo steel after pre-heat treatment (annealing,quenching, tempering) and treatment of quenching from dual phase range + tempering at high temperature ( also referred to as quenching from
席志伟, 罗红梅, 孙国栋
doaj
Sudden Changes in Water Hardness Do Not Impact Short-Term Rainbow Trout Survival
Fishes, 2022 Fish transferred from hard water to soft water, as can occur during the stocking of hatchery-reared fish into natural environments, experience many physiological stressors that can cause mortality.
Nathan Huysman +3 more
doaj +1 more source
The incomplete beta function law for parallel tempering sampling of classical canonical systems
, 2003 We show that the acceptance probability for swaps in the parallel tempering Monte Carlo method for classical canonical systems is given by a universal function that depends on the average statistical fluctuations of the potential and on the ratio of the ...
Ciobanu, Cristian V. +2 more
core +1 more source
Decorrelation of the topological charge in tempered Hybrid Monte Carlo simulations of QCD [PDF]
, 1999 We study the improvement of simulations of QCD with dynamical Wilson fermions by combining the Hybrid Monte Carlo algorithm with parallel tempering.
Allés +7 more
core +2 more sources
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Computational inference in systems biology [PDF]
, 2015 Parameter inference in mathematical models of biological pathways, expressed as coupled ordinary differential equations (ODEs), is a challenging problem. The computational costs associated with repeatedly solving the ODEs are often high.
A. Lotka +9 more
core +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Adaptive parallel tempering for BEAST 2
bioRxiv, 2019 With ever more complex models used to study evolutionary patterns, approaches that facilitate efficient inference under such models are needed. Parallel tempering has long been used to speed up phylogenetic analyses and to make use of multi-core CPUs ...
Nicola F. Müller, R. Bouckaert
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin +6 more
wiley +1 more source