Results 41 to 50 of about 77,192 (246)

Functional lesional neurosurgery for tremor—a protocol for a systematic review and meta-analysis [PDF]

, 2017
INTRODUCTION The recent introduction of incision-less lesional neurosurgery using Gamma Knife and MRI-guided focused ultrasound has revived interest in lesional treatment options for tremor disorders.
Krauss, Joachim K, Georg Kaegi, Chang, Jin Woo, Kägi, Georg, Joachim K Krauss, Bhatia, Kailash P, Jin Woo Chang, Sebastian R Schreglmann, Kailash P Bhatia, Schreglmann, Sebastian R   +9 more
core   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Robot-assisted retroperitoneal lymphadenectomy: The state of art

Asian Journal of Urology, 2021
Objective: To perform a narrative review about the role of robot-assisted retroperitoneal lymphadenectomy (R-RPLND) in the management of testicular cancer.
Gilberto J. Rodrigues, Giuliano B. Guglielmetti, Marcelo Orvieto, Kulthe Ramesh Seetharam Bhat, Vipul R. Patel, Rafael F. Coelho   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Patient-specific Implants for Orbital Fractures: A Systematic Review

, 2022
Purpose: Orbital fractures are common facial fractures that can be challenging to repair and require careful attention to avoid unacceptable ophthalmic complications.
E Ben Artsi (14632313), Stella May Gwini (13071999), DI Maher (14632310), AJ Hall (3939527)   +3 more
core  

Statistical Methods for the evaluation of hospital outcomes using routinely collected administrative data: a scoping review protocol

, 2022
Objective: The objective of this scoping review is to describe the alternative statistical methods used to evaluate hospital services using routinely collected observational data in Australia.
Jonathan Karnon, Aubyn Pincombe
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Attributes of family physician encounters valued by older adults: a systematic review

BMC Primary Care
Background Older adults (aged ≥ 65) are frequent users of primary care services, often presenting with unique values, needs, expectations, and preferences for family physician encounters compared to patients of younger ages.
Rebecca H. Correia, Darly Dash, Zain Pasat, Ryan P. Strum, Komal Aryal, Humayun Kabir, Maya Potter, Elaine Swayze, Pat Beaudoin, Pat Ward, Henry Yu-Hin Siu   +10 more
doaj   +1 more source

Organizational health culture in the Korean firefighter intervention studies: a scoping review

Frontiers in Public Health
IntroductionThis study examines the current state of intervention studies focused on Korean firefighters, who face unique health challenges due to the demands of their work and specific organizational culture.
Hanbit Jin, Hanbit Jin, Hyungsun Jun, Jisu Ha, Inae Youn, Jungtae Leem, Jungtae Leem, Jungtae Leem   +7 more
doaj   +1 more source

Racial and Ethnic Disparities in Adult Vaccination: A Review of the State of Evidence

Health Equity, 2022
Background: Adult vaccination coverage remains low in the United States, particularly among racial and ethnic minority populations. Objective: To conduct a comprehensive literature review of research studies assessing racial and ethnic disparities in ...
doaj   +1 more source