Results 101 to 110 of about 111,928 (240)

Brønsted Base-Catalyzed Aminoxylation of Benzylic and Allylic Compounds with TEMPO. [PDF]

Org Lett
Kondoh A, Terada M.
europepmc   +1 more source

Tempo, Tempo, Tempo - et intervju med meg selv

, 2018
Skriftlig obligatorisk arbeid levert som del av MA avslutningsarbeid ved Avdeling Kunstakademiet ...
openaire   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Electrochemical Activation of α-Carbonyl Alkoxyamines for Direct Nucleophilic Substitution. [PDF]

Org Lett
Putziger J, Kandahari E, Lin S.
europepmc   +1 more source

Pan2‐Pan3 Complex‐Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus

Advanced Science, EarlyView.
Discovery that deadenylation, rather than transcription, acts as the rate‐limiting step for developmental timing in a plant pathogen. Evidence that P‐body integrity and mRNA decay are mechanistically coupled to rapid cellular differentiation under environmental stress. Identification of Pan2‐Pan3 as a pathogen‐specific “meta‐virulence factor” absent in
Ziwei Lv, Junting Feng, Shenxian Zhou, Zhiguang Qu, Jun Peng, Xiao‐Lin Chen, Deng Chen   +6 more
wiley   +1 more source

High Potential Isoindoline-Based Nitroxides Posolytes for Aqueous Organic Redox Flow Batteries. [PDF]

ChemSusChem
Boutamine K, Casano G, Bassil P, Gauden S, Poderi C, Pepe E, Favier F, Le Vot S, Ouari O.   +8 more
europepmc   +1 more source

Tempo do sujeito, tempo do mundo, tempo da clínica

Revista Subjetividades, 2004
Ao comparar as concepções do tempo clássico da física e do tempo da subjetividade, o texto coloca em questão, na dimensão do “tempo vivido”, a tese da primazia do futuro, e na dimensão do “tempo do mundo”, a tese da primazia do presente. Algumas considerações complementares dizem respeito ao sentido do tempo na psicanálise, em especial no trauma e no ...
openaire   +2 more sources

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Nitroxide Hormesis in Yeast: 4-Hydroxy-TEMPO Modulates Aging, and Cell Cycle. [PDF]

Molecules
Mołoń M, Kielar P, Molestak E, Mołoń A, Kuna E, Biesiadecki M, Grela P, González-Ibarra A, Galiniak S.   +8 more
europepmc   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source