Results 31 to 40 of about 239,117 (241)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Temporal and spatial distribution of semicarbazide in western Laizhou Bay

, 2016
Semicarbazide (SEM), an industrial raw material and the marker residue of nitrofurazone as a veterinary drug, has become a new type of marine pollutant. A standard method (ultra-performance liquid chromatography-tandem mass spectrometry, UPLC-MS/MS) was ...
Liu, YH, Zhou, QL, Xia, CH (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China., Xia, CH, Song, XK, Gong, XH, Wang, ZQ, Xia, CH (reprint author), Ludong Univ, Yantai 264025, Peoples R China. Email:article0535@163.com, Xu, YJ, Tian, XH   +9 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Research on Temporal and Spatial Distribution Characteristics of Microseismic Events of Slip-Type Rockburst

Shock and Vibration, 2022
Based on the microseismic monitoring data of underground cavern of Shuangjiangkou Hydropower Station, the internal relationship between rockburst and microseismic events is analyzed and the occurrence mechanism of slip-type rockburst in underground ...
Kun Xu, Leibo Song, Wenjie Song, Jiangtao He, Liping Li, Ge Yan, Qin Chen, Gang Wang   +7 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Temporal and spatial distribution characteristics of the Ming Great Wall

Heritage Science
The Great Wall during the Ming Dynasty (1368–1644) was the most prominent engineering volume and the most perfect military defense structure in the history of China.
Yang Yang, Yukun Zhang, Yan Li
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

A Study on Characteristics of Mesoscale Convective Systems in East China Based on GPM Data

Gaoyuan qixiang
Based on GPM data from March 2014 to July 2023， the spatial and temporal distribution characteristic of mesoscale convective systems （MCSs） and sub-mesoscale convective systems （sub-MCSs） in East China are studied.Then the macro and micro structure ...
Lei ZHANG, Jing DUAN, Cheng XU, Hui WANG, Ying CHENG, Shujie JIANG, Xuanxuan HUANG   +6 more
doaj   +1 more source

Spatial-temporal Variation and Driving Forces of Water Yield in Harbin City

Shuitu baochi tongbao, 2023
[Objective] The spatial-temporal variation characteristics of water yield services in Harbin City, Heilongjiang Province from 2000 to 2020 were determined, and the driving mechanism of the spatial-temporal differentiation characteristics of Harbin City’s
Qi Yuxin, Hu Yuandong
doaj   +1 more source