Results 151 to 160 of about 249,722 (211)

Application of humanized mice in the safety experiments of antibody drugs

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun, Mengyun Gu, Zixuan Yang, Lei Shi, Liyuan Zhao, Minhui Zheng, Yan Wang, Wei Zhang, Kexin Han, Naping Tang   +9 more
wiley   +1 more source

Biocompatibility and healing patterns in experimentally induced canine tibial fractures using Pedicle screw‐Rod external fixation

Animal Models and Experimental Medicine, EarlyView.
This study demonstrates that using a Pedicle screw‐Rod configuration for the external fixation of non‐articular tibial osteotomy aligns well with the principles of biological osteosynthesis, resulting in secondary bone healing characterized by callus formation and neovascularization.
Mohammad Mahdi Gooran, Ramin Mazaheri‐Khameneh, Seyed Mohammad Hashemi‐Asl, Rahim Hobbenaghi   +3 more
wiley   +1 more source

Harnessing μ‐X‐Ray Fluorescence Spectroscopy as a Tool to Assess Extracellular Vesicle‐Induced Biomineralization

Advanced NanoBiomed Research, EarlyView.
This study presents an innovative approach to evaluate cell‐mediated biomineralization using μ‐X‐ray fluorescence spectroscopy. By generating elemental maps, the evaluation of mineral deposition by osteoblasts can be assessed in terms of both spatial distribution and degree of maturity.
Mathieu Y. Brunet, Adam McGuinness, Kenny Man, Marie‐Christine Jones, Sophie C. Cox   +4 more
wiley   +1 more source

Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers

Advanced NanoBiomed Research, EarlyView.
Lanthanide‐based luminescence nanothermometry holds multifaceted potential for nanomedical applications, yet despite significant research advances, clinical translation of the engineered nanomaterials is still controversial and widely disputed. This is related to crucial nanotoxicological aspects that must be addressed at the preclinical level ...
Simona Premcheska, Andre G. Skirtach, Anna M. Kaczmarek   +2 more
wiley   +1 more source

Potential Application of a Water‐Soluble Fullerene C60 Decorated with Diethylene Glycol in Treatment of Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
A new ethoxyethanol derivative of iminofullerene, F2, is synthesized and labeled with 99mTc to produce 99mTc‐F2. In vitro, compound F2 inhibits the activation of primary mouse bone marrow‐derived macrophages stimulated with lipopolysaccharide. Moreover, 99mTc‐F2 is selectively enriched in the injured joints of mice. Inflammatory macrophages play a role
Rui He, Alyssa Costello, Yanjie Liu, Weicheng Wang, Zhichang Zhang, Quanjun Cui, Xinlin Yang   +6 more
wiley   +1 more source

Who was the real sabertooth predator: Thylacosmilus or Thylacoleo?

The Anatomical Record, EarlyView.
Abstract Sabertoothed mammalian predators, all now extinct, were almost exclusively feloid carnivorans (Eutheria, Placentalia): here a couple of extinct metatherian predators are considered in comparison with the placental sabertooths. Thylacosmilus (the “marsupial sabertooth”) and Thylacoleo (the “marsupial lion”) were both relatively large (puma ...
Christine M. Janis
wiley   +1 more source

Early synapsids neurosensory diversity revealed by CT and synchrotron scanning

The Anatomical Record, EarlyView.
Abstract Non‐mammaliaform synapsids (NMS) represent the closest relatives of today's mammals among the early amniotes. Exploring their brain and nervous system is key to understanding how mammals evolved. Here, using CT and Synchrotron scanning, we document for the first time three extreme cases of neurosensory and behavioral adaptations that probe ...
J. Benoit, R. Araujo, E. S. Lund, A. Bolton, T. Lafferty, Z. Macungo, V. Fernandez   +6 more
wiley   +1 more source

Thrombocytopenia and Anemia After Cardiac Surgery

American Journal of Hematology, EarlyView.
Myriam Beshai, Nour Alhomsi, Theodore E. Warkentin   +2 more
wiley   +1 more source

Comparing cranial biomechanics between Barbourofelis fricki and Smilodon fatalis: Is there a universal killing‐bite among saber‐toothed predators?

The Anatomical Record, EarlyView.
Abstract Saber‐tooths, extinct apex predators with long and blade‐like upper canines, have appeared iteratively at least five times in the evolutionary history of vertebrates. Although saber‐tooths exhibit a relatively diverse range of morphologies, it is widely accepted that all killed their prey using the same predatory behavior. In this study, we CT‐
Borja Figueirido, Shane Tucker, Stephan Lautenschlager   +2 more
wiley   +1 more source

Morphological diversity of saber‐tooth upper canines and its functional implications

The Anatomical Record, EarlyView.
Abstract Elongated upper canine teeth, commonly known as saber‐teeth, have evolved three times within the sub‐order Feliformia. The species that wielded them flourished throughout the Cenozoic and have historically been separated into two morphological groups: the dirk‐tooths with longer, flatter canines, and the scimitar‐tooths with shorter, serrated ...
Caitlin D. Shelbourne, Stephan Lautenschlager   +1 more
wiley   +1 more source