Results 61 to 70 of about 437,871 (312)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A Case of McCune–Albright Syndrome with External Auditory Canal Stenosis Treated with Image-Guided Surgery System-Assisted Temporal Bone Surgery

Journal of International Advanced Otology
McCune–Albright syndrome is a disorder of fibrous bone dysplasia complicated by skin pigmentation and endocrine abnormalities. Although temporal bone lesions are rare, surgical treatment is required when external auditory canal (EAC) stenosis develops ...
Takaomi Kurioka, Tatsuya Takenaka, Shingo Yasutake, Yoshiaki Inuzuka, Motohiro Sato, Kunio Mizutari   +5 more
doaj   +1 more source

Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance [PDF]

, 2015
Finite element analysis (FEA) is a modelling technique increasingly used in anatomical studies investigating skeletal form and function. In the case of the cranium this approach has been applied to both living and fossil taxa to (for example) investigate
Barak, Benazzi, Berthaume, Bright, Bright, Chamoli, Cox, Curtis, Daegling, Dechow, Fagan, Fitton, Fitton, Gross, Gröning, Gröning, Gröning, Gröning, Horgan, Jansen van Rensburg, Keyak, Kupczik, Kupczik, Lengsfeld, Lieberman, Liu, Marinescu, McElhaney, Menegaz, Meredith, Milne, Misch, Moazen, Moss, O'Higgins, O'Higgins, O'Higgins, Olesiak, Peterson, Rayfield, Renders, Ross, Schwartz-Dabney, Smith, Smith, Strait, Strait, Szwedowski, Toro-Ibacache, Truesdell, Turner-Walker, Wang, Wood, Wroe, Yang, Yang   +55 more
core   +2 more sources

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

Evolution and Stagnation of Image Guidance for Surgery in the Lateral Skull: A Systematic Review 1989–2020

Frontiers in Surgery, 2021
Objective: Despite three decades of pre-clinical and clinical research into image guidance solutions as a more accurate and less invasive alternative for instrument and anatomy localization, translation into routine clinical practice for surgery in the ...
Daniel Schneider, Jan Hermann, Fabian Mueller, Gabriela O'Toole Bom Braga, Lukas Anschuetz, Marco Caversaccio, Lutz Nolte, Stefan Weber, Thomas Klenzner   +8 more
doaj   +1 more source

Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis. [PDF]

, 2010
DNAX adaptor protein 12 (DAP12) is a trans-membrane adaptor molecule that transduces activating signals in NK and myeloid cells. Absence of functional Dap12 results in osteoclast defects and bone abnormalities.
Adamopoulos, Iannis E, Antonenko, Svetlana, Bigler, Michael E, Blumenschein, Wendy M, Bowman, Edward P, Chao, Cheng-Chi, Cua, Daniel J, Heyworth, Paul G, Joyce-Shaikh, Barbara, McClanahan, Terrill K, Murphy, Erin E, Phillips, Joseph H   +11 more
core   +3 more sources

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Prognostic Impact of Tumor Extension in Patients With Advanced Temporal Bone Squamous Cell Carcinoma

Frontiers in Oncology, 2020
Objective: The extreme rarity of temporal bone squamous cell carcinoma (TB-SCC) has delayed the accumulation of high-quality clinical evidence. Our objective here was to explore anatomical factors associated with the prognosis of T4 TB-SCC cases.Study ...
Noritaka Komune, Masaru Miyazaki, Kuniaki Sato, Koji Sagiyama, Akio Hiwatashi, Takahiro Hongo, Kensuke Koike, Teppei Noda, Ryutaro Uchi, Ryunosuke Kogo, Nana Akagi Tsuchihashi, Shogo Masuda, Takashi Nakagawa   +12 more
doaj   +1 more source

Endoscopic Transnasal Approaches to Petrous Apex

Frontiers in Surgery, 2022
Endoscopic extended transnasal approaches to the apex of the temporal bone pyramid are rapidly developing and are widely used in our time around the world.
Alexander Kovalev, Rinat Sufianov, Daniel Prevedello, Luís Borba, Luís Borba, Luciano Mastronardi, Luciano Mastronardi, Tatiana Ilyasova, Roy Thomas Daniel, Mahmoud Messerer, Marcio Rassi, Marcio Rassi, Guang Zhang   +12 more
doaj   +1 more source

Osteocytes as a record of bone formation dynamics: A mathematical model of osteocyte generation in bone matrix [PDF]

, 2014
The formation of new bone involves both the deposition of bone matrix, and the formation of a network of cells embedded within the bone matrix, called osteocytes.
Buenzli, Pascal R
core   +3 more sources