Results 121 to 130 of about 7,354,713 (293)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Temporal Edge Attention Recurrent Neural Network for Violence Detection

四川大学学报. 自然科学版, 2023
Violence detection is one of the most important research topic in behavior recognition，which has great potential applications in network information review and intelligent security.The published works cannot keep their performance in the complexity ...
LIU Bang-Yi, ZHOU Ji-Liu, ZHANG Wei-Hua
doaj  

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Temporal context and the perceptions of geriatric patients [PDF]

Social Science & Medicine, 1982
The prevalence in later life of long-term, chronic conditions requires that researchers and clinical professionals become sensitive to the temporal context of older persons' personal and health-related perceptions. A sample of patients at a geriatric ambulatory clinic responded to a questionnaire sent prior to their appointment.
openaire   +3 more sources

Constructing and Forgetting Temporal Context in the Human Cerebral Cortex

bioRxiv, 2019
How does information from seconds earlier affect neocortical responses to new input? Here, we used empirical measurements and computational modeling to study the integration and forgetting of prior information.
H. Chien, C. Honey
semanticscholar   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Waiting for reward: preference for signalled delays increases with average wait time

Animal Cognition
When rewards occur after a delay, signals that the wait will be shorter than average can be valuable. A recent study by Macias et al. (2024) found that pigeons preferred an alternative providing signals for a short or long delay to food over an ...
Margaret A. McDevitt, Jeffrey M. Pisklak, Roger M. Dunn, Marcia L. Spetch   +3 more
doaj   +1 more source

Real-time tracking of surgical instruments based on spatio-temporal context and deep learning

Computer Assisted Surgery, 2019
ABSTARCT Real-time tool tracking in minimally invasive-surgery (MIS) has numerous applications for computer-assisted interventions (CAIs). Visual tracking approaches are a promising solution to real-time surgical tool tracking, however, many approaches ...
Zijian Zhao, Zhaorui Chen, S. Voros, Xiaolin Cheng   +3 more
semanticscholar   +1 more source