Results 81 to 90 of about 7,479,882 (285)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Spatio Temporal Context Target Tracking Algorithm of Self-adaption Learning [PDF]

Jisuanji gongcheng, 2018
For the traditional Spatio Temporal Context target tracking(STC) algorithm,no change of tracking’s window for a long time leads to learning space context model does not have a targeted problem when the target scale changes.This paper proposes a Spatio ...
ZHANG Jing,WANG Xu,FAN Hongbo
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

liu-temporal-processing-dataset

, 2018
Behavioral analysis processed dataset accompanying the paper "Temporal processing and context dependency in *C. elegans* mechanosensation"See README.md for more details.
Andrew M Leifer (4918549), Mochi Liu (4918396), Anuj K Sharma (4918552), Joshua W Shaevitz (4918546)   +3 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Comparative Analysis of the Functioning of Prepositions / Postpositions and Conjunctions as Means of Expressing the Category of Precedence in the Tatar and Russian Languages

Polylinguality and Transcultural Practices
This article presents a semantic-syntactic analysis of prepositions / postpositions and conjunctions of the Tatar and Russian languages with the semantics of precedence.
Gulnara F. Lutfullina
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Learning Temporal Context for Activity Recognition

, 2016
We investigate how incremental learning of long-term human activity patterns improves the accuracy of activity classification over time. Rather than trying to improve the classification methods themselves, we assume that they can take into account prior probabilities of activities occurring at a particular time.
Coppola C., Krajnik T., Duckett T., Bellotto N.   +3 more
openaire   +2 more sources

Dynamic Delegation Based on Temporal Context

Procedia Computer Science, 2016
AbstractDelegation is a very important part of the administrative process in access control systems; it provides resiliency and flexibility regarding to the management procedure. Delegation is the process of granting a specific authorization from a user to another user of the same system to carry out some functions on his behalf.
Ouarda Bettaz, Boustia Narhimene, Aïcha Mokhtari   +2 more
openaire   +2 more sources

Temporal context calibrates interval timing [PDF]

Nature Neuroscience, 2010
We use our sense of time to identify temporal relationships between events and to anticipate actions. The degree to which we can exploit temporal contingencies depends on the variability of our measurements of time. We asked humans to reproduce time intervals drawn from different underlying distributions.
Jazayeri, Mehrdad, Shadlen, Michael N.
openaire   +2 more sources