Results 111 to 120 of about 7,594,062 (311)

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

A Unified Spatio-Temporal Inference Network for Car-Sharing Serial Prediction

Sensors
Car-sharing systems require accurate demand prediction to ensure efficient resource allocation and scheduling decisions. However, developing precise predictive models for vehicle demand remains a challenging problem due to the complex spatio-temporal ...
Nihad Brahimi, Huaping Zhang, Syed Danial Asghar Zaidi, Lin Dai   +3 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

MRI-based intra-tumoral ecological diversity features and temporal characteristics for predicting microvascular invasion in hepatocellular carcinoma

Frontiers in Oncology
ObjectiveTo investigate the predictive value of radiomics models based on intra-tumoral ecological diversity (iTED) and temporal characteristics for assessing microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC).Material and ...
Yuli Zeng, Huiqin Wu, Yanqiu Zhu, Chao Li, Dongyang Du, Yang Song, Sulian Su, Jie Qin, Guihua Jiang, Guihua Jiang, Guihua Jiang   +10 more
doaj   +1 more source

Complex spatio-temporal features in meg data

Mathematical Biosciences and Engineering, 2006
Magnetoencephalography (MEG) brain signals are studied using a method for characterizing complex nonlinear dynamics. This approach uses the value of d(infinity) (d-infinite) to characterize the system's asymptotic chaotic behavior. A novel procedure has been developed to extract this parameter from time series when the system's structure and laws are ...
F. SAPUPPO, E. UMANA, FRASCA, MATTIA, M. LA ROSA, D. SHANNAHOFF KHALSA, FORTUNA, Luigi, BUCOLO, MAIDE ANGELA RITA   +6 more
openaire   +5 more sources

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

A Temporally Dynamic Feature-Extraction Framework for Phishing Detection with LIME and SHAP Explanations

Future Internet
Phishing remains one of the most pervasive social engineering threats, exploiting human vulnerabilities and continuously evolving to bypass static detection mechanisms.
Chris Mayo, Michael Tchuindjang, Sarfraz Brohi, Nikolaos Ersotelos   +3 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Anomaly detection method for coal mine sensor data

Gong-kuang zidonghua
In response to persistent dense noise anomalies, instantaneous impulse anomalies, and missing anomalies in sensor data caused by the complex underground environment of coal mines, existing data anomaly detection methods have difficulty adapting to ...
YANG Yuqi, FU Xiang, ZHANG Zhixing, YAN Ming, LI Haojie, LIU Bin, NIU Penghao, HUANG Jinyu   +7 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source