Results 141 to 150 of about 494,000 (315)

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Glaciochemical evidence of spatial and temporal environmental variability across Svalbard

, 2012
Huippuvuorten lakijäätiköiltä kairatut jäänäytteet ovat osoittautuneet hyödyllisiksi arkistoiksi, jotka kattavat useita vuosisatoja ja kertovat Barentsin alueen paleoympäristöstä sekä alueen ilmaston kytköksistä Euroopan arktisiin alueisiin.
Beaudon, Emilie
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Spatial and temporal variability of macrophyte cover and productivity in the eastern Amazon floodplain: A remote sensing approach

, 2010
Herbaceous aquatic macrophytes cover extensive areas on the floodplains of the Amazon basin and are an important habitat and input of organic carbon.
Melack, John M, Silva, Thiago Sanna Freire, Costa, Maycira P F   +2 more
core   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Quantifying temporal change in biodiversity : challenges and opportunities

, 2012
Growing concern about biodiversity loss underscores the need to quantify and understand temporal change. Here, we review the opportunities presented by biodiversity time series, and address three related issues: (i) recognizing the characteristics of ...
Gaston, Kevin J, Kosnik, M A, Morlon, H, Øvreås, L, Kosnik, Matthew A, McGill, B, Gaston, Kevin J., Colwell, Robert K., Gotelli, Nicholas J., Buckland, Stephen Terrence, Chao, Anne, Gotelli, N J, Buckland, Stephen T., Gaston, K J, Vellend, M, Ovreås, Lise, Chazdon, Robin L, Studeny, Angelika, Curtis, Tom, Kosnik, Matthew A., Buckland, S T, McCune, Jenny L, Mumby, P J, Mumby, Peter J., Morlon, Hélène, Gotelli, Nicolas J, Mumby, Peter J, Studeny, A, Curtis, T, Dornelas, Maria, McCune, J L, Dornelas, M, Colwell, R K, Chazdon, Robin L., McGill, Brian, Colwell, Robert K, Vellend, Mark, Magurran, Anne, Magurran, Anne E., Chao, A, Øvreås, Lise, Magurran, A E, McCune, Jenny L.   +42 more
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Permeability of intertidal sandflats: impact of temporal variability on sediment metabolism

, 2013
The effects of sediment permeability on sediment oxygen consumption (SOC) in an intertidal permeable sandflat were studied over a 1-year period. Our study demonstrates that temporal variation in sediment metabolism was not only driven by temperature, but
Bulling, Mark T., Witte, U., Zetzche, E.
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