Results 101 to 110 of about 531,027 (318)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Temporal Variation in the Interest-Rate Response to Money Announcements [PDF]

A number of studies find significant temporal variation in the interest-rate response to money announcement surprises. An unresolved question, however, is whether the response changes immediately as different policy regimes are adopted, or whether the ...
Simon M. Wheatley, V. Vance Roley
core  

Spatio-temporal population modelling for enhanced assessment of urban exposure to flood risk [PDF]

, 2016
There is a growing need for high resolution spatio-temporal population estimates which allow accurate assessment of population exposure to natural hazards.
David Martin, Alan Smith, Smith, Alan, Martin, David J., Cockings, Samantha, Samantha Cockings   +5 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Temporal Variation in Trophic Cascades [PDF]

, 2017
The trophic cascade has emerged as a key paradigm in ecology. Although ecologists have made progress in understanding spatial variation in the strength of trophic cascades, temporal variation remains relatively unexplored.
Amber N. Wright, Wright, Amber N, Louie H. Yang, Piovia-Scott, Jonah, Yang, Louie H, Jonah Piovia-Scott   +5 more
core   +1 more source

Temporal Difference Variational Auto-Encoder

, 2018
To act and plan in complex environments, we posit that agents should have a mental simulator of the world with three characteristics: (a) it should build an abstract state representing the condition of the world; (b) it should form a belief which represents uncertainty on the world; (c) it should go beyond simple step-by-step simulation, and exhibit ...
Karol Gregor, George Papamakarios, Frederic Besse, Lars Buesing, Theophane Weber   +4 more
openaire   +3 more sources

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

WISER Deliverable D3.3-2: The importance of invertebrate spatial and temporal variation for ecological status classification for European lakes [PDF]

European lakes are affected by many human induced disturbances. In principle, ecological theories predict that the structure and functioning of benthic invertebrate assemblage (one of the Biological Quality Elements following the Water Framework ...
Mastrantuono, L., Pilotto, F., Sandin, L., Munch, E., Michels, M., Dunbar, M., Clarke, Ralph T., Bazzanti, M., Verdonschot, P., McGoff, E., Porst, G., Bader, S., Solimini, A., Pusch, M.   +13 more
core  

Seasonal effects of wastewater to the water quality of the Caeté river estuary, Brazilian Amazon

Anais da Academia Brasileira de Ciências, 2010
Bragança's socioeconomic situation is highly dependent on estuarine and marine biological resources that are influenced by tidal cycles and climatology. Field measurements (hydrological, hydrodynamic and microbiological variables) were taken in the most ...
Luci C.C. Pereira, Marcela C. Monteiro, Danielly O. Guimarães, Jislene B. Matos, Rauquírio M. da Costa   +4 more
doaj   +1 more source

Temporal variation in prehistoric Nubian crania [PDF]

American Journal of Physical Anthropology, 1976
AbstractMuch of the earlier work on the prehistory of Sudanese Nubia has emphasized discontinuity between early Nubian populations. However, recent investigations suggest the converse ‐ that a remarkable degree of cultural and biological continuity exists among indigenous Nubian groups, perhaps as far back as the Paleolithic.
openaire   +2 more sources