Results 151 to 160 of about 114,370 (386)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Development and characterization of composites consisting of woven fabrics with integrated prismatic shaped cavities [PDF]

open access: yes, 2016
Composites are extensively used in automotive, construction, airplanes, wind turbines etc. because of their good mechanical properties such as high specific stiffness, high specific strength and resistance against fatigue. The main issues with composites
De Baere, Ives   +4 more
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Generality, Specificity And Discovery [PDF]

open access: yes
This paper offers a meta-theory concerning the relation between the general and the specific in science. This issue was recently called back to attention by Hodgson (2001). A heuristic of discovery, developed in earlier work (Nooteboom 1992, 1996, 1999b,
Nooteboom, B.
core   +1 more source

NYS PROMISE Learning Community Group Concept Mapping: Fall 2016 Case Manager Experience - Final Report [PDF]

open access: yes, 2017
Beginning in 2014, the Federal Government provided funding to New York State as part of an initiative to improve services that lead to sustainable outcomes for youth receiving Supplemental Security Income (SSI) benefits.
Golden, Thomas P   +2 more
core   +1 more source

The Tenacity of the Rehabilitative Ideal Revisited

open access: green, 1998
Jody L. Sundt   +3 more
openalex   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Proceedings of the 11th European Agent Systems Summer School Student Session [PDF]

open access: yes
This volume contains the papers presented at the Student Session of the 11th European Agent Systems Summer School (EASSS) held on 2nd of September 2009 at Educatorio della Providenza, Turin, Italy.
Balke, Tina (Ed.)   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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