Results 191 to 200 of about 114,370 (386)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Impact of Lignin Type on Yield and Fiber Morphology in Biobased Carbon Fiber Precursors. [PDF]

open access: yesACS Omega
Bengtsson J   +6 more
europepmc   +1 more source

Testing airplane fabrics [PDF]

open access: yes
The following considerations determine the strength of airplane fabrics: 1. maximum air forces acting on the surfaces (including local stresses); 2. tensions produced in the fabrics, in the directions of both warp and filling; 3.
Proll, A
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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