Results 81 to 90 of about 98,513 (288)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Potential contribution of high strength, high modulus aramid fibers to the commercial feasibility of lighter than air craft [PDF]

, 1975
Kevlar aramid fiber, fabric, rope and cable performance are reviewed along with the economics relevant to the material, structural, and reliability aspects of lighter than air ...
Sturgeon, D. L. G., Venkatachalam, T. K.
core   +1 more source

Rheological Properties of Modified Crumb Rubber Asphalt Binder and Selecting the Best Modified Binder Using AHP Method [PDF]

, 2019
Crumb rubber modifier (CRM) is one of the most popular asphalt binder modifiers due to the economic benefits and desired physical and rheological properties of asphalt binders and asphalt mixes.
Amirkhanian, Serji, Jadidi, Kazem, Khalili, Mehdi   +2 more
core   +2 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Business Model Innovation: Impact of Entrepreneurial Competencies to New Value Proposition

Business Systems Research
Rapid changes and dynamic markets significantly impact the way businesses operate. Many companies fail to adapt and innovate their business models, which jeopardises their sustainability.
Turulja Lejla, Smajlović Selma, Šimičević Vanja   +2 more
doaj   +1 more source

IMPACT OF TWIST FACTOR ON THE PHYSICAL AND STRUCTURAL PROPERTIES OF JUTE YARN LINEAR DENSITY [PDF]

European Journal of Materials Science and Engineering
This study investigates the effect of twist factors on the tensile properties of jute yarns with linear densities of 193, 213, and 251 tex. The yarns were twisted to four levels: 1460, 2420, 2820, and 3056 turns per metre x √Tex.
EKUNDAYO Gbenga , GONG Hugh, ABEYKOON Chamil   +2 more
doaj   +1 more source

A virtue epistemology of the Internet: Search engines, intellectual virtues and education [PDF]

, 2017
This paper applies a virtue epistemology approach to using the Internet, as to improve our information-seeking behaviours. Virtue epistemology focusses on the cognitive character of agents and is less concerned with the nature of truth and epistemic ...
Heersmink, Richard
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Viscose Rayon: An Absorbing Problem. An Investigation into the Impact Conservation Wet Cleaning Treatments have on Historic Woven Viscose Rayon Fabrics; with a Supplementary Analysis of Current Techniques for Identifying Man-Made Fibres [PDF]

, 2013
Viscose rayon has been in production for over a century, however, minimal literature is available on its conservation. Pre-1940s viscose rayon has poorer wet strength than later versions.
Gamper, Charlotte, Quye, Anita, Thompson, Karen   +2 more
core