Results 61 to 70 of about 1,680,252 (377)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Impact des phénomènes climatiques extrêmes sur les ressources en eau et l’agriculture au Maroc
Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2019 Si le Maroc est un pays faiblement émetteur de gaz à effet de serre, il reste cependant vulnérable à l’impact du changement climatique dû aux spécificités que lui confèrent sa position géographique et sa dépendance vis-à-vis des secteurs sensibles au ...
Mohamed AOUBOUAZZA +2 more
doaj
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
L’accouchement par césarienne en Turquie : décision médicale ou tendance imposée ?
Anthropologie & SantéThe cesarean section delivery rate in Turkey is currently the highest among OECD member countries, and has increased from 21% in 2002 to 62,8 % in 2022. Despite the introduction of the “Caesarean section law” in 2012, this rate has not declined.
Selen Göbelez
doaj +1 more source
Promotion de la santé et prévention des maladies chroniques au Canada, 2020 Introduction. La majorité des études sur l’exposition à la fumée du tabac et la qualité du sommeil se fondent sur le tabagisme autodéclaré, ce qui peut entraîner des erreurs de classification de l’exposition et des biais liés à l’autodéclaration.
Moe Zandy +3 more
doaj +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
La signifiance d’une thématique des oiseaux chez Giono et Le Clézio
Revue des Langues, Cultures et Sociétés, 2019 L’attachement pour la nature se trouve rapporté à un désir de renverser une tendance à l’ère actuelle. En effet, la modernité a notamment engendré la perte à tout jamais de certaines espèces animales.
Jean Florent Romaric GNAYORO
doaj +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source