Results 81 to 90 of about 1,680,252 (377)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Bon anniversaire : l’expérience de Nuevo Mundo
Nuevo mundo - Mundos Nuevos, 2010 Le texte retrace brièvement l'histoire de la revue Nuevo Mundo, Mundos Nuevos ainsi que ses enjeux intellectuels. Il insiste sur les conditions difficiles de fabrication d'un objet unique et souligne les acquis: l'histoire du très contemporain, l ...
Carmen Bernand
doaj +1 more source
Globalization and Worker Welfare in Late Nineteenth Century Europe [PDF]
This paper asks whether the trend toward convergence in late nineteenth century Europe depends on the welfare measure used. We construct a Worker Development Index (WDI) composed of Williamson's real wage estimates, and new series of work hours and labor
Michael Huberman, Wayne Lewchuk
core
ong et Développement Agricole Au Burkina Faso: Présence Majeure et Effets Mineurs [PDF]
, 1994 This report analyses the effect of NGO participation on Agriculture ...
Alain Piveteau
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Etude Sur la Stratégie et le Programme D'appui à la Société Civile Burundaise [PDF]
, 2002 The author study's strategies and programs to build civil society in ...
Christophe Sebudandi, Gérard Nduwayo
core
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Dynamique des matières en suspension dans un bief de la rivière lot
Knowledge and Management of Aquatic Ecosystems, 1976 Des bilans amont-aval ont été réalisés sur le bief de Cajarc : réservoir artificiel de 3 km de long et 1 269 000 m3 sur la rivière Lot. Les paramètres suivants ont été étudiés sur des cycles de 24 heures pour différents débits : matières minérales et ...
MASSIO J. C., DECAMPS H.
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source