Results 1 to 10 of about 25,713 (223)

Animal model for tendinopathy

Journal of Orthopaedic Translation, 2023
Background: Tendinopathy is a common motor system disease that leads to pain and reduced function. Despite its prevalence, our mechanistic understanding is incomplete, leading to limited efficacy of treatment options.
Junchao Luo, Zetao Wang, Chenqi Tang, Zi Yin, Jiayun Huang, Dengfeng Ruan, Yang Fei, Canlong Wang, Xianan Mo, Jiajin Li, Jun Zhang, Cailian Fang, Jianyou Li, Xiao Chen, Weiliang Shen   +14 more
doaj   +2 more sources

Platelet-rich plasma in the pathologic processes of tendinopathy: a review of basic science studies

Frontiers in Bioengineering and Biotechnology, 2023
Tendinopathy is a medical condition that includes a spectrum of inflammatory and degenerative tendon changes caused by traumatic or overuse injuries.
Jialin Lu, Jialin Lu, Han Li, Ziyu Zhang, Rui Xu, Jincheng Wang, Hui Jin, Hui Jin   +7 more
doaj   +2 more sources

Inhibition of Integrin αvβ6 Activation of TGF‐β Attenuates Tendinopathy

Advanced Science, 2022
Tendinopathy is a common tendon disorder that causes pain and impairs function. It is the most common reason for consultation with musculoskeletal specialists.
Xiao Wang, Shen Liu, Tao Yu, Senbo An, Ruoxian Deng, Xiaohua Tan, Janet Crane, Weixin Zhang, Dayu Pan, Mei Wan, Andrew Carr, Xu Cao   +11 more
doaj   +2 more sources

NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a “One-Stone-Two-Birds” manner

Journal of Nanobiotechnology, 2023
Background Tendinopathy is the leading sports-related injury and will cause severe weakness and tenderness. Effective therapy for tendinopathy remains limited, and extracellular vesicles (EVs) derived from adipose tissue-derived mesenchymal stem cells ...
Guanghao Wu, Qihang Su, Jie Li, Chao Xue, Jie Zhu, Qiuchen Cai, Jingbiao Huang, Shaoyang Ji, Biao Cheng, Hengan Ge   +9 more
doaj   +2 more sources

Large animal models for the study of tendinopathy

Frontiers in Cell and Developmental Biology, 2022
Tendinopathy has a high incidence in athletes and the aging population. It can cause pain and movement disorders, and is one of the most difficult problems in orthopedics. Animal models of tendinopathy provide potentially efficient and effective means to
Guorong Zhang, Guorong Zhang, Xuyan Zhou, Shuang Hu, Ye Jin, Zhidong Qiu   +5 more
doaj   +2 more sources

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response [PDF]

Advanced Science
Tendinopathy represents a major musculoskeletal health problem, yet its pathogenesis remains poorly understood. Tendinopathy development is studied in humans with early ( 3 months, n = 16) (CT) patellar tendinopathy and in healthy subjects (n = 15) (CTRL)
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
doaj   +2 more sources

Single-cell and spatial transcriptomics reveal changes in cell heterogeneity during progression of human tendinopathy

BMC Biology, 2023
Background Musculoskeletal tissue degeneration impairs the life quality and motor function of many people, especially seniors and athletes. Tendinopathy is one of the most common diseases associated with musculoskeletal tissue degeneration, representing ...
Weili Fu, Runze Yang, Jian Li
doaj   +2 more sources

Large extracellular vesicles secreted by human iPSC-derived MSCs ameliorate tendinopathy via regulating macrophage heterogeneity

Bioactive Materials, 2023
Tendinopathy is a common musculoskeletal disorder which results in chronic pain and reduced performance. The therapeutic effect of stem cell derived-small extracellular vesicles (sEVs) for tendinopathy has been validated in recent years. However, whether
Teng Ye, Zhengsheng Chen, Jieyuan Zhang, Lei Luo, Renzhi Gao, Liangzhi Gong, Yuhang Du, Zongping Xie, Bizeng Zhao, Qing Li, Yang Wang   +10 more
doaj   +2 more sources

Classification of distinct tendinopathy subtypes for precision therapeutics

Nature Communications
Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy.
Chenqi Tang, Zetao Wang, Yuanhao Xie, Yang Fei, Junchao Luo, Canlong Wang, Yue Ying, Peiwen He, Ruojing Yan, Yangwu Chen, Jiayun Huang, Yiwen Xu, Zicheng Wang, Boon Chin Heng, Hengzhi Liu, Jianyou Li, Zi Yin, Haobo Wu, Weishan Chen, Hongwei Ouyang, Xiao Chen, Weiliang Shen   +21 more
doaj   +2 more sources

Achilles tendinopathy.

Foot and Ankle Surgery, 2020
BACKGROUND Achilles Tendinopathy (AT) is essentially a failed healing response with haphazard proliferation of tenocytes, abnormalities in tenocytes with disruption of collagen fibers, and subsequent increase in non-collagenous matrix.
N. Maffulli, U. Longo, A. Kadakia, F. Spiezia   +3 more
semanticscholar   +4 more sources