Results 1 to 10 of about 31,979 (227)

18-β-glycyrrhetinic acid facilitates nuclear-mitochondrial communications to alleviate oxidative stress through HMGB1-cGAS-Mul1 axis in tendinopathy [PDF]

Journal of Translational Medicine
Background Tendinopathy is a prevalent orthopaedic condition characterized by disrupted tendon homeostasis, with oxidative stress being a key contributing mechanism.
Yuan-Yuan Gao, Wen-Shuang Sun, Zi-Ying Sun, Jun-Rui Wang, Zhong-Yang Lv, Yu-Jia Li, Hao-Yuan Tian, Zheng-Yang Bao, Xin-Ran Qiu, Zheng Wang, Shi-Zhong Zheng, Jiang-Juan Shao, Zi-Li Zhang, Jia Meng   +13 more
doaj   +2 more sources

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response [PDF]

Advanced Science
Tendinopathy represents a major musculoskeletal health problem, yet its pathogenesis remains poorly understood. Tendinopathy development is studied in humans with early ( 3 months, n = 16) (CT) patellar tendinopathy and in healthy subjects (n = 15) (CTRL)
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
doaj   +2 more sources

The clinical diagnosis of Achilles tendinopathy: a scoping review [PDF]

PeerJ, 2021
Background Achilles tendinopathy describes the clinical presentation of pain localised to the Achilles tendon and associated loss of function with tendon loading activities.
Wesley Matthews, Richard Ellis, James Furness, Wayne A. Hing   +3 more
doaj   +2 more sources

Prevalence, risk factors and treatment outcomes of fluoroquinolones-associated tendinopathy in tuberculosis patients at university hospital, Thailand

Heliyon, 2023
Background: Tuberculosis (TB) is an epidemic disease in Thailand. Fluoroquinolones are used to treat TB and have a lengthy treatment course. Therefore, many patients may have adverse effects from these medications.
Jirarat Chongboonwatana, Varalee Terbsiri, Gompol Suwanpimolkul   +2 more
doaj   +1 more source

Inhibition of Integrin αvβ6 Activation of TGF‐β Attenuates Tendinopathy

Advanced Science, 2022
Tendinopathy is a common tendon disorder that causes pain and impairs function. It is the most common reason for consultation with musculoskeletal specialists.
Xiao Wang, Shen Liu, Tao Yu, Senbo An, Ruoxian Deng, Xiaohua Tan, Janet Crane, Weixin Zhang, Dayu Pan, Mei Wan, Andrew Carr, Xu Cao   +11 more
doaj   +1 more source

Large animal models for the study of tendinopathy

Frontiers in Cell and Developmental Biology, 2022
Tendinopathy has a high incidence in athletes and the aging population. It can cause pain and movement disorders, and is one of the most difficult problems in orthopedics. Animal models of tendinopathy provide potentially efficient and effective means to
Guorong Zhang, Guorong Zhang, Xuyan Zhou, Shuang Hu, Ye Jin, Zhidong Qiu   +5 more
doaj   +1 more source

Nearly half of patients with chronic tendinopathy may have a neuropathic pain component, with significant differences seen between different tendon sites: a prospective cohort of more than 300 patients

BMJ Open Sport & Exercise Medicine, 2022
Objectives Identifying the prevalence of neuropathic pain components in patients with chronic tendinopathy conditions using the Self-Administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) questionnaire.Methods Patients with chronic ...
Patrick C Wheeler
doaj   +1 more source

Clinical Association of Achilles Tendinopathy and Hypertension Mediated by CaV1.2 Voltage-gated Ca2+ Channel

Foot & Ankle Orthopaedics, 2023
Category: Basic Sciences/Biologics; Hindfoot Introduction/Purpose: The Achilles tendon is subject to acute- and overuse-injuries, which may result in degenerative tendinopathy.
David J. Ciufo MD, Chike Cao PhD, Christopher Mendias PhD, ATC, Haiyin Li MD, PhD   +3 more
doaj   +1 more source

Impact of Patellar Tendinopathy on Isokinetic Knee Strength and Jumps in Professional Basketball Players

Sensors, 2021
Patellar tendinopathy is characterized by tendon pain which may reduce the level of performance. This study’s main aim was to compare isokinetic knee strength and jump performances at the start of the sport season between players with patellar ...
Marc Dauty, Pierre Menu, Olivier Mesland, Bastien Louguet, Alban Fouasson-Chailloux   +4 more
doaj   +1 more source

Animal model for tendinopathy

Journal of Orthopaedic Translation, 2023
Background: Tendinopathy is a common motor system disease that leads to pain and reduced function. Despite its prevalence, our mechanistic understanding is incomplete, leading to limited efficacy of treatment options.
Junchao Luo, Zetao Wang, Chenqi Tang, Zi Yin, Jiayun Huang, Dengfeng Ruan, Yang Fei, Canlong Wang, Xianan Mo, Jiajin Li, Jun Zhang, Cailian Fang, Jianyou Li, Xiao Chen, Weiliang Shen   +14 more
doaj   +1 more source