Results 131 to 140 of about 36,306 (295)

Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression by tenocytes [PDF]

, 2013
Repetitive strain or ‘overuse’ is thought to be a major factor contributing to the development of tendinopathy. The aims of our study were to develop a novel cyclic loading system, and use it to investigate the effect of defined loading conditions on the
Jones, Gavin, Legerlotz, K, Riley, GP, Screen, HRC   +3 more
core   +1 more source

HMGB1 mediates the development of tendinopathy due to mechanical overloading.

PLoS ONE, 2019
Mechanical overloading is a major cause of tendinopathy, but the underlying pathogenesis of tendinopathy is unclear. Here we report that high mobility group box1 (HMGB1) is released to the tendon extracellular matrix and initiates an inflammatory cascade
Guangyi Zhao, Jianying Zhang, Daibang Nie, Yiqin Zhou, Feng Li, Kentaro Onishi, Timothy Billiar, James H-C Wang   +7 more
doaj   +1 more source

Ready or Not; A Narrative Synthesis of Sports Medicine Practitioners' Practices During Return to Play in the Management of Musculoskeletal Injuries

European Journal of Sport Science, Volume 25, Issue 11, November 2025.
ABSTRACT The purpose of this narrative synthesis was to identify and synthesise the literature focused on sports medicine practitioners' (SMPs) decision‐making practices during return to play (RTP) after musculoskeletal (MSK) injury. Using the Preferred Items for Reporting Systematic Reviews and Meta‐Analyses guidelines, four electronic databases were ...
Megan Chetty, Gregory Roe, Ben Jones, Sharief Hendricks   +3 more
wiley   +1 more source

Heat shock proteins in tendinopathy: novel molecular regulators [PDF]

, 2012
Tendon disorders-tendinopathies-are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations.
Millar, N.L., Murrell, G.A.C.
core   +3 more sources

Introduction of a New Index as an Indicator for Achilles Tendon Tendinopathy

Foot & Ankle Orthopaedics, 2019
Category: Sports Introduction/Purpose: Achilles tendon tendinopathy is a common problem in our daily practice. The initial therapy consists of conservative treatment and usually leads to a reduction of pain.
Stephan Wirth MD, Fabian Aregger, Anna Jungwirth-Weinberger, Thorsten Jentzsch MD, MSc, Andreas Hecker MD   +4 more
doaj   +1 more source

Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This review provides an intriguing review of the recent advancements, challenges, and future perspectives regarding the application of piezoelectric scaffolds in tissue regeneration. The detailed exposition is anticipated to propel the advancement of personalized and intelligent piezoelectric implants, thereby fostering significant progress in this ...
Xiaoling Deng, Yu Zhuang, Jinjie Cui, Liyun Wang, Huilu Zhan, Xudong Wang, Kaili Lin, Changyong Yuan   +7 more
wiley   +1 more source

DNA‐Based Hydrogels for Musculoskeletal Reconstruction: Harnessing Dynamic Programmability and Multimodal Therapeutic Integration

Advanced Science, Volume 12, Issue 39, October 20, 2025.
DNA‐based hydrogels serve dual roles as structural scaffolds and therapeutic platforms, offering innovative solutions for musculoskeletal regeneration with multifunctional abilities. Abstract Musculoskeletal disorders, including bone fractures, osteoarthritis, and muscle injuries, represent a leading cause of global disability, revealing the urgency ...
Ruijianghan Shi, Huilu Zhan, Shan Jiang, Kaili Lin, Changyong Yuan   +4 more
wiley   +1 more source

Tissue-engineered mesenchymal stem cell constructs alleviate tendinopathy by suppressing vascularization

Bioactive Materials
Tendinopathy leads to low-grade tissue inflammation and chronic damage, which progresses due to pathological imbalance in angiogenesis. Reducing early pathological vascularization may be a new approach in helping to regenerate tendon tissue. Conventional
Dijun Li, Jingwei Jiu, Haifeng Liu, Xiaojun Yan, Xiaoke Li, Lei Yan, Jing Zhang, Zijuan Fan, Songyan Li, Guangyuan Du, Jiao Jiao Li, Yanan Du, Wei Liu, Bin Wang   +13 more
doaj   +1 more source

Near‐normal ultrasound morphology in quadriceps tendon after anterior cruciate ligament graft harvest

Journal of Experimental Orthopaedics, Volume 12, Issue 4, October 2025.
Abstract Purpose The quadriceps tendon (QT) autograft is increasingly used for anterior cruciate ligament reconstruction (ACLR) due to favourable clinical outcomes. However, the long‐term morphological and vascular changes at the QT harvest site remain unclear.
Jumpei Inoue, Kohei Kamada, Keishi Takaba, M. Enes Kayaalp, Joseph D. Giusto, Bryson P. Lesniak, Andrew L. Sprague, Volker Musahl   +7 more
wiley   +1 more source

Mitochondrial destabilization in tendinopathy and potential therapeutic strategies

Journal of Orthopaedic Translation
Tendinopathy is a prevalent aging-related disorder characterized by pain, swelling, and impaired function, often resulting from micro-scarring and degeneration caused by overuse or trauma.
Linxiang Cheng, Qiangqiang Zheng, Kaijie Qiu, Dai Fei Elmer Ker, Xiao Chen, Zi Yin   +5 more
doaj   +1 more source