Results 51 to 60 of about 17,502 (187)

Achilles tenocytes from diabetic and non diabetic donors exposed to hyperglycemia respond differentially to inflammatory stimuli and stretch

Journal of Anatomy, EarlyView.
Scheme depicting the experimental set up of the study. Achilles tendons and tenocytes were isolated from heterozygous (fa/+, non diabetic: non DMT2) and homozygous (fa/fa, diabetic: DMT2) Zucker Diabetic Fatty (ZDF) rats. Tendon degeneration, collagen type 1 alpha 1 chain (COL1A1) and alpha smooth muscle actin (αSMA) expression was determined in rat ...
Nils Fleischmann, Sarah Hofmann, Clemens Gögele, Eva Frank, Christian Werner, Maria Kokozidou, Bernd Hoffmann, Jens Konrad, Gundula Schulze‐Tanzil   +8 more
wiley   +1 more source

Large extracellular vesicles secreted by human iPSC-derived MSCs ameliorate tendinopathy via regulating macrophage heterogeneity

Bioactive Materials, 2023
Tendinopathy is a common musculoskeletal disorder which results in chronic pain and reduced performance. The therapeutic effect of stem cell derived-small extracellular vesicles (sEVs) for tendinopathy has been validated in recent years. However, whether
Teng Ye, Zhengsheng Chen, Jieyuan Zhang, Lei Luo, Renzhi Gao, Liangzhi Gong, Yuhang Du, Zongping Xie, Bizeng Zhao, Qing Li, Yang Wang   +10 more
doaj  

Effect of human myoblasts on tenogenic progression in 2D and 3D culture models

Journal of Anatomy, EarlyView.
We investigated whether factors released from muscle derived myogenic cells enhance tenogenic progressions of human tendon derived cells using two‐dimensional (2D) culture model and a three‐dimensional (3D)‐engineered tendon construct culture model.
Yoshifumi Tsuchiya, Ching‐Yan Chloé Yeung, Rene B. Svensson, Michael Kjaer   +3 more
wiley   +1 more source

Classification of distinct tendinopathy subtypes for precision therapeutics

Nature Communications
Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy.
Chenqi Tang, Zetao Wang, Yuanhao Xie, Yang Fei, Junchao Luo, Canlong Wang, Yue Ying, Peiwen He, Ruojing Yan, Yangwu Chen, Jiayun Huang, Yiwen Xu, Zicheng Wang, Boon Chin Heng, Hengzhi Liu, Jianyou Li, Zi Yin, Haobo Wu, Weishan Chen, Hongwei Ouyang, Xiao Chen, Weiliang Shen   +21 more
doaj   +1 more source

Computed microtomographic imaging of revascularization during healing of Achilles tendon injury

Journal of Anatomy, EarlyView.
This study explores the role of vascularization in tendon healing by comparing physiological and pathological angiogenesis. Using micro‐CT imaging, we identified distinct changes in vascular organization following injury, highlighting the dynamic interplay between angiogenesis and tendon pathology.
Mert Ocak, Seher Yilmaz, Sefa Burak Çam, Burak Bilecenoğlu, Barış Özgür Dönmez, Petek Korkusuz, Ozan Akkus   +6 more
wiley   +1 more source

Inertial Flywheel Resistance Training in Tendinopathy Rehabilitation: A Scoping Review

International Journal of Sports Physical Therapy, 2022
# Background Inertial Flywheel Resistance Training (IFRT) has recently emerged as a beneficial rehabilitation option for some musculoskeletal disorders.
Ian Burton, Aisling McCormack
doaj   +1 more source

High‐voltage pulsed radiofrequency of the suprascapular nerve for the treatment of chronic shoulder pain

PM&R, EarlyView.
Javier García‐Amigo, B. Cabaleiro‐Burguillos, Carlos Cordero‐García   +2 more
wiley   +1 more source

Antebrachial conformation in Cocker Spaniels with and without humeral intracondylar fissure

Veterinary Surgery, EarlyView.
Abstract Objective To objectively quantify antebrachial morphology from computed tomography (CT) scans of Cocker Spaniels with and without humeral intracondylar fissure (HIF). Study design Retrospective imaging. Methods Three‐dimensional (3D) rendered CT scans of the antebrachii of Cocker Spaniels with HIF (Group 1), or without HIF but with medial ...
Neil J. Burton, Vinny Davies, Tim H. Sparks   +2 more
wiley   +1 more source

HMGB1 mediates the development of tendinopathy due to mechanical overloading.

PLoS ONE, 2019
Mechanical overloading is a major cause of tendinopathy, but the underlying pathogenesis of tendinopathy is unclear. Here we report that high mobility group box1 (HMGB1) is released to the tendon extracellular matrix and initiates an inflammatory cascade
Guangyi Zhao, Jianying Zhang, Daibang Nie, Yiqin Zhou, Feng Li, Kentaro Onishi, Timothy Billiar, James H-C Wang   +7 more
doaj   +1 more source

Exploring cellular changes in ruptured human quadriceps tendons at single‐cell resolution

The Journal of Physiology, EarlyView.
Abstract figure legend This study explores the cellular landscape of healthy and ruptured quadriceps tendons using single nucleus RNA sequencing. While a range of stromal and immune cell types and subsets were identified, the data indicate that fibroblasts and endothelial cells are the main drivers of the early injury response within ruptured ...
Jolet Y. Mimpen, Mathew J. Baldwin, Claudia Paul, Lorenzo Ramos‐Mucci, Alina Kurjan, Carla J. Cohen, Shreeya Sharma, Marie S. N. Chevalier Florquin, Philippa A. Hulley, John McMaster, Andrew Titchener, Alexander Martin, Matthew L. Costa, Stephen E. Gwilym, Adam P. Cribbs, Sarah J. B. Snelling   +15 more
wiley   +1 more source