Results 51 to 60 of about 20,699 (227)

Increased expression of glutathione peroxidase 3 prevents tendinopathy by suppressing oxidative stress

Frontiers in Pharmacology, 2023
Tendinopathy, a degenerative disease, is characterized by pain, loss of tendon strength, or rupture. Previous studies have identified multiple risk factors for tendinopathy, including aging and fluoroquinolone use; however, its therapeutic target remains
Haruka Furuta, Mari Yamada, Takuya Nagashima, Shuichi Matsuda, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko   +6 more
doaj   +1 more source

Achilles tendinopathy : evaluation and treatment [PDF]

, 2001
. Background: Achilles tendinopathy is considered to be one of the most common overuse injuries in elite and recreational athletes. There are, however, only a few randomized studies of treatment and there is a need for standardized outcome measures for ...
Grävare Silbernagel, Karin, Gräväre Silbernagel, K., Thomee, P., Karlsson, Jan, Thomee, R.   +4 more
core   +1 more source

NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a “One-Stone-Two-Birds” manner

Journal of Nanobiotechnology, 2023
Background Tendinopathy is the leading sports-related injury and will cause severe weakness and tenderness. Effective therapy for tendinopathy remains limited, and extracellular vesicles (EVs) derived from adipose tissue-derived mesenchymal stem cells ...
Guanghao Wu, Qihang Su, Jie Li, Chao Xue, Jie Zhu, Qiuchen Cai, Jingbiao Huang, Shaoyang Ji, Biao Cheng, Hengan Ge   +9 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Longitudinal Changes in Adiposity after a Youth Sport‐Related Knee Injury: Informing Post‐Traumatic Osteoarthritis Prevention

Arthritis Care &Research, Accepted Article.
Objective Youth who experience a sport‐related knee injury have elevated odds of overweight or obesity in 3‐10 years, compounding their risk for post‐traumatic osteoarthritis (PTOA). To inform prevention strategies, this study compared patterns of adiposity change between youth with a sport‐related knee injury and uninjured youth in the 2‐year period ...
Justin M. Losciale, Nuria EJ Jansen, Christina Y. Le, Leo Lu, Hui Xie, Marienke van Middelkoop, Jackie L. Whittaker   +6 more
wiley   +1 more source

Proteomics of tendinopathy

Frontiers in Bioscience, 2009
Recent advances in the basic understanding of both human biology and animal models have enabled an unprecedented level of information to be gathered about the genetic regulation of human disease. However, a corresponding insight into functional interactions between genetic information and protein expression has been slower to accumulate. Measuring mRNA
openaire   +2 more sources

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science
Tendinopathy represents a major musculoskeletal health problem, yet its pathogenesis remains poorly understood. Tendinopathy development is studied in humans with early ( 3 months, n = 16) (CT) patellar tendinopathy and in healthy subjects (n = 15) (CTRL)
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
doaj   +1 more source

Large extracellular vesicles secreted by human iPSC-derived MSCs ameliorate tendinopathy via regulating macrophage heterogeneity

Bioactive Materials, 2023
Tendinopathy is a common musculoskeletal disorder which results in chronic pain and reduced performance. The therapeutic effect of stem cell derived-small extracellular vesicles (sEVs) for tendinopathy has been validated in recent years. However, whether
Teng Ye, Zhengsheng Chen, Jieyuan Zhang, Lei Luo, Renzhi Gao, Liangzhi Gong, Yuhang Du, Zongping Xie, Bizeng Zhao, Qing Li, Yang Wang   +10 more
doaj   +1 more source

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source

Notoginsenoside R1 attenuates tendinopathy through inhibiting inflammation and matrix metalloproteinases expression

Frontiers in Pharmacology
Research purposeThe purpose of this study is to demonstrate the effectiveness of Notoginsenoside R1 (NGR1) in treating tendinopathy and to reveal its potential mechanisms.Materials and methodsThis study performed a preliminary network-based assessment of
Qingxin Han, Junying Wu, Yan Li, Yi Tong, Xiaohua Liu, Xiaoqing Hu, Lei Zhang   +6 more
doaj   +1 more source