Results 121 to 130 of about 862,528 (395)

Cellular distribution and gene expression profile during flexor tendon graft repair: A novel tissue engineering approach

Journal of Tissue Engineering, 2013
To understand scar and adhesion formation during postsurgical period of intrasynovial tendon graft healing, a murine model of flexor digitorum longus tendon graft repair was developed, by utilizing flexor digitorum longus tendon allograft from donor ...
Subhash C Juneja
doaj   +1 more source

Tendon reattachment to bone in an ovine tendon defect model of retraction using allogenic and xenogenic demineralised bone matrix incorporated with mesenchymal stem cells [PDF]

, 2016
BACKGROUND: Tendon-bone healing following rotator cuff repairs is mainly impaired by poor tissue quality. Demineralised bone matrix promotes healing of the tendon-bone interface but its role in the treatment of tendon tears with retraction has not been ...
Alexander, Susan, Blunn, Gordon W., Lambert, Simon, Pendegrass, Catherine J., Shahbazi, Shirin, Thangarajah, Tanujan   +5 more
core   +3 more sources

Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing

Scientific Reports, 2017
To date, the cell and molecular mechanisms regulating tendon healing are poorly understood. Here, we establish a novel model of tendon regeneration using neonatal mice and show that neonates heal via formation of a ‘neo-tendon’ that differentiates along ...
Kristen L. Howell, Chun Chien, R. Bell, D. Laudier, S. Tufa, D. Keene, N. Andarawis-Puri, A. Huang   +7 more
semanticscholar   +1 more source

Fibrillar Bundles as Fibrous Filler Materials for Attaining Cell Anisotropy in Bioprinting

Advanced Healthcare Materials, EarlyView.
Fibrillar bundles are introduced as a bioprintable additive that enables robust and scalable cellular alignment within 3D constructs through flow‐induced orientation during extrusion. These fibers support strong cell adhesion and polarization across various cell types and significantly enhance myotube alignment in Gelatine‐Methacryloyl (GelMA ...
Sven Heilig, Zan Lamberger, Lys Sprenger, Vivien Priebe, Camilla Mussoni, Denitsa Docheva, Kristina Andelovic, Jürgen Groll, Sahar Salehi, Gregor Lang, Matthias Ryma   +10 more
wiley   +1 more source

Self‐Assembling Peptide Hydrogels Support Stromal Vascular Fraction Viability to Promote In Vivo Nerve Regeneration

Advanced Healthcare Materials, EarlyView.
Stromal vascular fraction (SVF) may enhance nerve repair, especially when delivered in a self‐assembling peptide hydrogel (SAPH). In vitro, softer SAPH increased neuronal explant outgrowth and supported greater SVF viability and proliferation. In a rat sciatic defect, SVF in an optimized SAPH produced motor and sensory recovery equivalent to autograft ...
Liam A. McMorrow, Steffan Llewellyn, Jared McSweeney, Alessandro Faroni, Aline F. Miller, Alberto Saiani, Adam J. Reid   +6 more
wiley   +1 more source

Endogenous musculoskeletal tissue engineering - a focused perspective [PDF]

, 2012
Two major difficulties facing widespread clinical implementation of existing Tissue Engineering (TE) strategies for the treatment of musculoskeletal disorders are (1) the cost, space and time required for ex vivo culture of a patient’s autologous cells ...
Adam, Clayton
core   +2 more sources

Adipose‐Derived Stromal Vascular Fraction and Cultured Stromal Cells as Trophic Mediators for Tendon Healing

Journal of Orthopaedic Research, 2019
Adipose‐derived stromal vascular fraction (SVF) is a heterogeneous population of cells that yields a homogeneous population of plastic‐adherent adipose tissue‐derived stromal cells (ASC) when culture‐expanded.
Shelley S. Polly, Anne E. C. Nichols, Elle K Donnini, D. Inman, Timothy J. Scott, Stephanie M. Apple, S. Werre, L. A. Dahlgren   +7 more
semanticscholar   +1 more source

Hybrid Scaffolds Decouple Biochemical & Biophysical Regulation of Cell Phenotype

Advanced Healthcare Materials, EarlyView.
Replicating tissue‐specific extracellular matrix is crucial for understanding its role in disease. This work demonstrates independent control over stiffness, composition and 3D collagen architecture using hybrid scaffolds: patterned collagen perfused with defined hydrogels.
Xinyuan Song, Samantha C. Mitchell, Abbie N. Smart, William Hardiman, Daniel V. Bax, Ceri E. Staley, Catherine Probert, Pamela Collier, Marian Meakin, Alison A. Ritchie, Tania Mendonca, Amanda J. Wright, Victoria James, Anna M. Grabowska, Catherine L. R. Merry, Serena M. Best, Ruth E. Cameron, Jennifer C. Ashworth   +17 more
wiley   +1 more source

Mechanisms of tendon-bone interface healing: biomechanics, cell mechanics, and tissue engineering approaches

Journal of Orthopaedic Surgery and Research
The healing of tendon-bone contact surfaces involves complex biomechanical and biochemical interactions, with pivotal implications for sports medicine and rehabilitation.
Zhixiong Xu, Wensheng Xu, Tao Zhang, Long Luo   +3 more
doaj   +1 more source

Dose-dependent new bone formation by extracorporeal shock wave application on the intact femur of rabbits [PDF]

, 2008
Background: Whereas various molecular working mechanisms of shock waves have been demonstrated, no study has assessed in detail the influence of varying energy flux densities (EFD) on new bone formation in vivo. Methods: Thirty Chinchilla bastard rabbits
Hausdorf, J., Maier, M., Milz, S., Pautke, C., Schmitz, C., Tischer, T., Weiler, C.   +6 more
core   +1 more source