Exposure of a tendon extracellular matrix to synovial fluid triggers endogenous and engrafted cell death: A mechanism for failed healing of intrathecal tendon injuries [PDF]
, 2016 Aim: The purpose of this study was to investigate the effect of normal synovial fluid (SF) on exposed endogenous tendon-derived cells (TDC) and engrafted mesenchymal stem cells (MSCs) within the tendon extracellular matrix. Methods: Explants from equine
Dudhia, J +3 more
core +3 more sources
Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing [PDF]
, 2017 Tendon injuries heal via scar tissue rather than regeneration. This healing response forms adhesions between the flexor tendons in the hand and surrounding tissues, resulting in impaired range of motion and hand function.
Ackerman, Jessica E +3 more
core +2 more sources
New Insights on the miRNA Role in Diabetic Tendinopathy: Adipose-Derived Mesenchymal Stem Cell Conditioned Medium as a Potential Innovative Epigenetic-Based Therapy for Tendon Healing. [PDF]
BiomoleculesRusso M +11 more
europepmc +3 more sources
I.S.Mu.L.T. Achilles Tendon Ruptures Guidelines [PDF]
, 2018 This work provides easily accessible guidelines for the diagnosis, treatment and rehabilitation of Achilles tendon ruptures. These guidelines could be considered as recommendations for good clinical practice developed through a process of systematic ...
Alessio Giai Via, +47 more
core +1 more source
EGR1 Regulates Transcription Downstream of Mechanical Signals during Tendon Formation and Healing. [PDF]
PLoS ONE, 2016 Tendon is a mechanical tissue that transmits forces generated by muscle to bone in order to allow body motion. The molecular pathways that sense mechanical forces during tendon formation, homeostasis and repair are not known.
Ludovic Gaut +5 more
doaj +1 more source
The role of the macrophage in tendinopathy and tendon healing
Journal of Orthopaedic Research, 2020 The role of the macrophage is an area of emerging interest in tendinopathy and tendon healing. The macrophage has been found to play a key role in regulating the healing process of the healing tendon.
Joo Y. Sunwoo +3 more
semanticscholar +1 more source
Mesenchymal stem cells and macrophages and their interactions in tendon-bone healing
Journal of Orthopaedic Translation, 2023 Tendon-bone insertion injuries (TBI), such as anterior cruciate ligament (ACL) and rotator cuff injuries, are common degenerative or traumatic pathologies with a negative impact on the patient's daily life, and they cause huge economic losses every year.
Zhuo Chen +8 more
doaj +1 more source
Di-san junyi daxue xuebao, 2019 Objective To evaluate the effect of mechanical stretching in promoting tendon healing and reducing tendon adhesion during the healing of extensor flexor tendon in rats and its effects on the expression of transforming growth factor-β3 (TGF-β3) and cyclic
LI Shuaifeng +4 more
doaj +1 more source
Establishing in vivo and ex vivo chick embryo models to investigate fetal tendon healing
Scientific Reports, 2023 Injured adult tendons heal fibrotically and possess high re-injury rates, whereas fetal tendons appear to heal scarlessly. However, knowledge of fetal tendon wound healing is limited due in part to the need for an accessible animal model.
Phong K. Nguyen +4 more
doaj +1 more source
Effects of immobilization angle on tendon healing after achilles rupture in a rat model [PDF]
Journal of Orthopaedic Research, 2019 Conservative (non‐operative) treatment of Achilles tendon ruptures is a common alternative to operative treatment. Following rupture, ankle immobilization in plantarflexion is thought to aid healing by restoring tendon end‐to‐end apposition.
Cody D. Hillin +6 more
openalex +2 more sources