The structure of a tendon is an important example of complexity of ECM three-dimensional organization. The extracellular matrix (ECM) is a macromolecular network with both structural and regulatory functions. ECM components belong to four major types of macromolecules: the collagens, elastin, proteoglycans, and noncollagenous glycoproteins. Tendons are
Tresoldi, I +6 more
openaire +5 more sources
Dielectrophoretic Characterization of Tenogenically Differentiating Mesenchymal Stem Cells
Tendons are collagenous musculoskeletal tissues that connect muscles to bones and transfer the forces necessary for movement. Tendons are susceptible to injury and heal poorly, with long-term loss of function.
Anthony T. Giduthuri +3 more
doaj +1 more source
Inhibition of Tendon Cell Proliferation and Matrix Glycosaminoglycan Synthesis by Non-Steroidal Anti-Inflammatory Drugs in vitro [PDF]
The purpose of this study was to investigate the effects of some commonly used non-steroidal anti-inflammatory drugs (NSAIDs) on human tendon. Explants of human digital flexor and patella tendons were cultured in medium containing pharmacological ...
B. L HAZLEMAN +16 more
core +1 more source
Versican splice variant messenger RNA expression in normal human Achilles tendon and tendinopathies [PDF]
Versican is the principal large proteoglycan expressed in mid-tendon, but its role in tendon pathology is unknown. Our objective was to define the expression of versican isoform splice variant messenger ribonucleic acid (mRNA) in normal Achilles tendons,
Corps, AN +6 more
core +2 more sources
Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing [PDF]
Tendon is composed of fascicles bound together by the interfascicular matrix (IFM). Energy storing tendons are more elastic and extensible than positional tendons; behaviour provided by specialisation of the IFM to enable repeated interfascicular sliding
A Heinz +48 more
core +4 more sources
Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds [PDF]
The patella (kneecap) exhibits multiple evolutionary origins in birds, mammals, and lizards, and is thought to increase the mechanical advantage of the knee extensor muscles.
Alexander +84 more
core +10 more sources
The Regulation of Aggrecanase ADAMTS-4 Expression in Human Achilles Tendon and tendon-Derived Cells [PDF]
Several members of the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) family have been identified as aggrecanases, whose substrates include versican, the principal large proteoglycan in the tendon extracellular matrix.
Corps, Anthony N. +5 more
core +2 more sources
Comparative Study between Scales: Subjective Elbow Value and Patient-rated Tennis Elbow Evaluation Applied to Patients Affected by Lateral Epicondylitis [PDF]
Objective To verify if the subjective elbow value (SEV) scale presents similar results to those of the Patient-rated Tennis Elbow Evaluation (PRTEE) scale in the evaluation of patients with lateral elbow epicondylitis (LEE).
Roberto Yukio Ikemoto +5 more
doaj +4 more sources
How does a cadaver model work for testing ultrasound diagnostic capability for rheumatic-like tendon damage? [PDF]
To establish whether a cadaver model can serve as an effective surrogate for the detection of tendon damage characteristic of rheumatoid arthritis (RA). In addition, we evaluated intraobserver and interobserver agreement in the grading of RA-like tendon ...
A Iagnocco +42 more
core +2 more sources
A Technical Review of the Simplified Approach to the Ultrasonography of the Elbow Joint
The elbow joint is a complex joint which serves as a mechanical link between the hand, wrist and shoulder in the upper extremity. Soft-tissue structures and joints of the human body are often assessed by ultrasonography.
Megha Bhargava +2 more
doaj +1 more source

