Results 121 to 130 of about 386,611 (339)

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

open access: yesAdvanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou   +13 more
wiley   +1 more source

Degradable and Recyclable 3D‐Printed Pheromones Delivery System Reinforced by Metal Coordination Cross‐Linking for Efficient Pest Trapping

open access: yesAdvanced Science, EarlyView.
This study presents a 3D‐printed carrier for the slow release of insect pheromones. Reinforced by lignosulfonate and Fe³⁺ coordination in a cellulose acetate matrix, it enables sustained release for up to six weeks with remarkable trapping efficacy. Featuring soil degradability and recyclable re‐printing capability, this carrier provides a sustainable ...
Teng Wang   +6 more
wiley   +1 more source

Additive‐Free Ti3C2Tx MXene Actuator with Large Deformation, Programmability, and High‐Humidity Stability via Precise Interlayer Spacing Control Engineering

open access: yesAdvanced Science, EarlyView.
By sequentially assembling MXene nanosheets with significant size differences, a multistimulus responsive additive‐free MXene actuator with gradient structure is obtained. An innovative cyclic low‐temperature annealing‐rehydration technology is proposed, which achieves precise control of interlayer d‐spacing, initial shape, and actuation behavior of ...
Haowen Zheng   +13 more
wiley   +1 more source

Size‐Dependent Ultrasound Activation of Thrombin Catalytic Activity by Mechano‐Nanoswitches

open access: yesAdvanced Science, EarlyView.
The fundamental principles linking nanoparticle (NP) physicochemical properties to their interactions with sonomechanical forces are not well‐defined. This work systematically investigates the size‐dependent ultrasound activation of thrombin using different‐sized mechano‐nanoswitches, which provides critical insights into the role of NP size in nano ...
Menghan Xiao   +9 more
wiley   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu   +11 more
wiley   +1 more source

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