Results 81 to 90 of about 9,684 (185)

Systemic pirfenidone treatment fails to mitigate fibrosis and compromises functional recovery in a porcine model of volumetric muscle loss

Experimental Physiology, EarlyView.
Abstract Repurposing clinically approved antifibrotic agents presents a potential near‐term therapeutic strategy to mitigate the extensive fibrotic scarring that follows severe volumetric muscle loss (VML) injury and inhibits functional recovery. We hypothesized that daily oral administration of pirfenidone, an FDA‐approved antifibrotic, would mitigate
Jessica M. Motherwell, Ondine Eken, Claudia E. Hernandez, Christopher L. Dearth, Stephen M. Goldman   +4 more
wiley   +1 more source

The Impact of Ageing on Skeletal Muscle: Roles of Mitochondrial Dysregulation, Systemic Communication, and Exercise

Journal of Cellular Physiology, Volume 241, Issue 8, August 2026.
ABSTRACT Ageing is a major risk factor for degenerative diseases, including sarcopenia, which is characterized by a progressive loss of skeletal muscle mass and function, frailty, and is associated with increased mortality. Skeletal muscle regeneration relies on muscle stem cells and efficient communication with cellular microenvironment.
Juan Diego Hernández‐Camacho, Marielle Saclier   +1 more
wiley   +1 more source

Application of Focused Ultrasound for the Treatment of Tendinopathy: An In Vivo Feasibility, Safety, and Efficacy Study

Journal of Orthopaedic Research, Volume 44, Issue 8, August 2026.
ABSTRACT Mechanical loading‐based rehabilitation of tendinopathies improves symptoms and tendon biomechanics, motivating interest in non‐invasive treatment options. Focused ultrasound (FUS) is a promising technology that precisely targets tissue regions, inducing desired bioeffects while minimally affecting surrounding tissues. To explore its potential
Chitra Meduri, Emily P. Rogers, Dylan C. Easley, P. Gunnar Brolinson, Eli Vlaisavljevich, Vincent M. Wang   +5 more
wiley   +1 more source

Prognostic Factors for Postoperative Complications. An Aggregate Protocol for 10 Observational Studies From the Danish TRIPLE‐A Cohort of 1.2 Million Surgeries

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Postoperative complications substantially increase morbidity, mortality and healthcare costs. Understanding prognostic factors is essential for risk stratification, targeted prevention strategies, and development of prediction models.
Anders Peder Højer Karlsen, Asta Prescott, Caroline Folkersen, Jens Laigaard, Atena Saito, Caroline Lando Klammer, Mik Wetterslev, Emil Ipsen Ørskov, Mathilde Fahrendorff, Rebecca Kiær, Helene Holm Laigaard, Nichlas Hovmand, Lars Hyldborg Lundstrøm, Sebastian Buhl Rasmussen, Anders Kehlet Nørskov, Markus Harboe Olsen   +15 more
wiley   +1 more source

A Matched-Pair Controlled Study of Arthroscopic Psoas Tenotomy with Minimum 2-Year Follow-Up

Orthopaedic Journal of Sports Medicine, 2015
Objectives: It is unknown whether pateints undergoing tenotomy for painful internal snapping at the time of hip arthroscopy can expect equivalent functional outcome to patients undergoing hip arthroscopy without tenotomy.
John M. Redmond MD, Aaron R. Schwartz MD, Asheesh Gupta MD, MPH, Christine E. Stake DHA, Nathan Finch MA, Benjamin G. Domb MD   +5 more
doaj   +1 more source

The Clinical Outcomes of Arthroscopic Tenotomy versus Tenodesis with Medium-to-Massive Rotator Cuff Tear in the Elderly: A Retrospective Study

Clinical Interventions in Aging
Kaihang Song,* Guanghua Lu,* Ming Cai, Qi Sun Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China*These authors contributed equally to this ...
Song K, Lu G, Cai M, Sun Q
doaj  

CONGENITAL CLUBFOOT TREATED BY PONSETI TECHNIQUE

Gomal Journal of Medical Sciences, 2017
Background: Clubfoot is a disease characterized by complex malformed feet or foot without the malformations of other bones and joints in the body. The objective of the study was to evaluate the conservative treatment of clubfoot in children by Ponseti ...
Shakeel Ahmad Shah, Aftab Ahmad, Muhammad Afaq Ali, Saim Mohammad   +3 more
doaj  

Arthroscopic T-shaped biceps tenotomy decreased risk of Popeye deformity compared to traditional biceps tenotomy

Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology
Purpose: This study compared the clinical efficacy of T-shaped biceps tenotomy (release of the long head of the biceps tendon with a portion of the superior labrum) with that of conventional cylinder-shaped biceps tenotomy (without the labrum) in ...
Yen-Wei Huang, Pu-Kuang Wang, Shen-Wu Hung, Yu-Pin Chen, Wei-chun Chang, Yi-Jie Kuo, Tai-Yuan Chuang   +6 more
doaj   +1 more source

Corrigendum: Transcriptional Time Course After Rotator Cuff Tear

Frontiers in Physiology, 2021
Laura S. Vasquez-Bolanos, Laura S. Vasquez-Bolanos, Michael C. Gibbons, Michael C. Gibbons, Severin Ruoss, Isabella T. Wu, Mario Vargas-Vila, Sydnee A. Hyman, Sydnee A. Hyman, Mary C. Esparza, Donald C. Fithian, John G. Lane, Anshuman Singh, Anshuman Singh, Chanond A. Nasamran, Kathleen M. Fisch, Samuel R. Ward, Samuel R. Ward, Samuel R. Ward   +18 more
doaj   +1 more source

Clinical and Ultrasonographic Outcomes of Percutaneous Achilles Tenotomy Using an 18-Gauge Needle in Idiopathic Clubfoot: A Prospective Study. [PDF]

J Orthop Case Rep
Kumar A, Gupta RK, Kalme B.
europepmc   +1 more source