Results 101 to 110 of about 1,007,262 (294)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Masker Medika, 2019 Latar Belakang: Gangguan yang sering kali terjadi pada genu adalah osteoarthritis. Osteoarthritis(OA) adalah penyakit degenerative sendi yang ditandai dengan kerusakan kartilago, disertai nyeri dan kekakuan.
Yudiansyah Yudiansyah +1 more
doaj
Informes de la Construcción, 1958 Para remediar la penuria que azota la falta de espacios libres para el estacionamiento de vehículos en las grandes ciudades, donde el tráfico rodado aumenta y congestiona continuamente la circulación, se decidió, por una empresa particular, la construcción de un garaje de tipo moderno, dotado de los servicios inherentes a esta clase de explotaciones ...
Grimes, Robert O., Bovay, H. E.
openaire +4 more sources
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Physical Treatments, 2016 Purpose: Rehabilitation and physiotherapy have a major role in reducing the pain and increasing the functional ability in patients with shoulder joint pain.
Ahmad Reza Askary Ashtiani +3 more
doaj
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Optimizing filter trap assay for the detection of aggregated alpha-synuclein in brain samples
Free Neuropathology, 2020 Thibauld Oullier +5 more
doaj +1 more source
Forcing of Climate Variations by Mev-gev Particles [PDF]
, 1990 Changes in ionization production in the lower stratosphere by a few percent during Forbush decreases have been shown to correlate well with changes in winter tropospheric dynamics by a similar relatively small amount.
Tinsley, Brian A.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source