Results 131 to 140 of about 361,101 (305)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Tension Control of Gpindle Winders.
Journal of the Textile Machinary Society, 1954 研究目的コーンワインダにはオープンワインド用ワインダと, プレサイズワインド用ワインダの2種類があろが, レーヨンの如きフィラメントヤーンを巻くには何れが適しているかを検討し, 次いでプレサイズワインドコーンを巻くに必要な種々の条件を求め, 特にテンションの調整は如何にすべきかを研究目的とし, レーヨンワインダの高速度化に対すろ可能性を求めんとした.研究結果1.レーヨンの如きフィラメントヤーンに対してはプレサイズスペイスドワインドが適していろ結果を示した.2.プレサイズワインドコーンを巻くにはコーンの内圧を一一定に保つ必要があり, この方法として糸に加えろテゾションを糸の巻取角度に比例させる場合と, プレッシャローラを用いろ場合の二っがあり, 各々の特徴はあるがレーヨンに対しては前者の方法が好ましい.
openaire +2 more sources
Dynamic tension control of cardboard packing machnine
, 2011 Työssä tutkitaan PI-säätimen käyttöä dynaamisessa kireydensäädössä ilman varsinaista kireyden takaisinkytkentää. Kireyttä säädetään epäsuorasti käyttämällä takaisinkytkentätietona kahden telan välistä paikkaeroa.
Nevaranta, Niko
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Advances in Mechanical EngineeringThe virtual microgravity training system based on cable drive usually uses a force-position hybrid control strategy which has following problems: the force control method is sensitive to load disturbances, variable stiffness characteristics of cables ...
Feng Xue +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source