Results 221 to 230 of about 15,140 (255)
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The efficacy and safety of terbinafine in children
Journal of the European Academy of Dermatology and Venereology, 2003ABSTRACTTerbinafine is an allylamine antifungal agent that has been effective and safe in the treatment of superficial and some deep mycotic infections in adults. An increasing amount of data is available where terbinafine has been used in the paediatric population to treat superficial fungal infections, in particular tinea capitis.
Elizabeth A. Cooper +2 more
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2003
Abstract Terbinafine is a newly developed oral and topical antifungal agent in the allylamine class of antifungal compounds (Petranyi et al, 1984). Discovered in 1983, it is closely related to naftifine. Terbinafine became available in Europe in 1991, and in 1996 in the United States.
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Abstract Terbinafine is a newly developed oral and topical antifungal agent in the allylamine class of antifungal compounds (Petranyi et al, 1984). Discovered in 1983, it is closely related to naftifine. Terbinafine became available in Europe in 1991, and in 1996 in the United States.
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Terbinafine-induced hepatic dysfunction
European Journal of Gastroenterology & Hepatology, 2001A 41-year-old man developed severe hepatic dysfunction following a 3.5-week course of terbinafine (250 mg/day). He suffered marked pruritus, jaundice, malaise, anorexia and loin pain. Serum bilirubin rose to a peak value of 718 micromol/l with alkaline phosphatase at 569 U/l, alanine aminotransferase at 90 U/l, aspartate aminotransferase at 63 U/l and ...
William M. Chambers +3 more
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Tissue distribution of terbinafine in rats
Journal of Pharmaceutical Sciences, 2001Terbinafine is an allylamine antifungal agent that is highly lipophilic and keratophilic. The aim of this study was to investigate terbinafine distribution in peripheral and visceral tissues after intravenous administration to rats. Terbinafine, 6 mg/kg, was administered to 33 male Sprague-Dawley rats via a jugular vein cannula over 30 s.
Mahboubeh Hosseini-Yeganeh +1 more
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Drug and chemical toxicology (New York, N.Y. 1978), 2020
There are an estimated 1 billion cases of superficial fungal infection globally. Fungal pathogens form biofilms within wounds and delay the wound healing process. Miconazole and terbinafine are commonly used to treat fungal infections.
P. Lam +11 more
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There are an estimated 1 billion cases of superficial fungal infection globally. Fungal pathogens form biofilms within wounds and delay the wound healing process. Miconazole and terbinafine are commonly used to treat fungal infections.
P. Lam +11 more
semanticscholar +1 more source
Management of onychomycosis with oral terbinafine
Journal of the American Academy of Dermatology, 1990The safety and efficacy of oral terbinafine in the treatment of finger onychomycosis caused by Trichophyton rubrum were evaluated in an open study including 11 patients. Treatment consisted of 125 mg of terbinafine given twice daily for 6 months or until the infection cleared.
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Oral terbinafine and erythema multiforme
Clinical and Experimental Dermatology, 1995Two patients developed classical erythema multiforme while taking oral terbinafine. A case of Stevens-Johnson syndrome occurring after terbinafine therapy has recently been described, but there have been no published reports of an association with erythema multiforme until now.
Dowling D. Munro, P. Todd, S.M. Halpern
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Therapeutic Review: Terbinafine
Journal of Exotic Pet Medicine, 2012al, U ard V Terbinafine is a synthetic allylamine antifungal used commonly in both human and veterinary medicine. Terbinafine inhibits squalene epoxidase, a key enzyme in ergosterol biosynthesis,1-4 thereby decreasing ergosterol synthesis and causing toxic levels of squalene to accumulate in the fungal cell.
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Preclinical evaluation of terbinafine in vivo
Clinical and Experimental Dermatology, 1989The fungicidal activity of terbinafine which has been demonstrated in vitro for several strains of dermatophyte, filamentous and dimorphic fungi, has been demonstrated in vivo in model systems for dermatophytoses. This activity is accompanied by a fast onset of action which leads to superior antifungal efficacy when compared with fungistatic drugs.
H. Mieth, G. Petranyi
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Mupirocin vs terbinafine in impetigo
The Indian Journal of Pediatrics, 2002Terbinafine is an antifungal drug known to have also antibacterial activity against certain Gram-positive and Gram-negative bacteria. It seems that antibacterial and antifungal activity of terbinafine may have an advantage in the treatment of mixed fungal and bacterial superficial skin infections.
Ahmet Derya Aysev +2 more
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