Results 241 to 250 of about 33,505 (332)

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Gannan rare earth elements cohort: study design, methods, and baseline characteristics of the cohort. [PDF]

BMC Public Health
Liu W, Huang L, Wang J, Lei Y, Yan F, Cao S, Jiang Z, Xu J, He Y, Wang F, Gui J, Guo Y, Chen W, Zhang X, Gao Y.   +14 more
europepmc   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Multimode Magneto-Optical Fiber Based on Borogermanate Glass Containing Tb³⁺ for Sensing Applications. [PDF]

Materials (Basel)
Franco DF, Morency S, Messaddeq Y, Nalin M.   +3 more
europepmc   +1 more source

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Anion Effects on the Structural and Magnetic Properties of a Series of Trinuclear Cu^II-Ln^III-Cu^II Complexes. [PDF]

ACS Omega
Matheson BE, Dais TN, Donaldson ME, Takeshi SI, Lyu L, Takano R, Ishida T, Rowlands GJ, Plieger PG.   +8 more
europepmc   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Developing Lanthanide-Nitrate Cluster Chemistry toward Rare Earth Separations. [PDF]

Inorg Chem
McCusker TL, Roseborough A, McDonald MA, Jackson SA, Redeker FA, Nyman M, Knope KE.   +6 more
europepmc   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Cross sections of [Formula: see text]Sm([Formula: see text]Li,x) reactions for the production of [Formula: see text]Tb for targeted alpha therapy. [PDF]

Sci Rep
Bills LA, McIntosh AB, Morrell JT, Adsley P, Abbott AD, Rojas DC, Garcia-Duarte J, Gott MD, Hagel K, Hankins T, Harke JT, Harvey BM, Hughes RO, McIntosh LA, Mishnayot Y, Mohs C, Picayo GA, Reuter M, Rider R, Santucci J, Sauceda S, Sorensen M, Tabacaru A, Tamashiro AS, Tereshatov EE, Thomas D, Tobin Z, Vermeulen CE, Wellons B, Yennello SJ.   +29 more
europepmc   +1 more source